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Details on Person Excision of 8-oxoguanine by OGG1 glycosylase

Class:Id	Reaction:110243
_displayName	Excision of 8-oxoguanine by OGG1 glycosylase
_doRelease	TRUE
_timestamp	2019-10-16 16:29:48
authored	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00
catalystActivity	[CatalystActivity:5643997] oxidized purine nucleobase lesion DNA N-glycosylase activity of OGG1:(8oxoG:Cyt)-dsDNA [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:110175] Matthews, L, 2004-01-29 08:00:00
edited	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00 [InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03 [InstanceEdit:9663704] Orlic-Milacic, Marija, 2019-10-10
input	[Complex:110185] OGG1:(8oxoG:Cyt)-dsDNA [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:5635989] Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue [LiteratureReference:5635981] Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase [LiteratureReference:5635964] Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase [LiteratureReference:5635990] Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae [LiteratureReference:5635965] Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites [LiteratureReference:5635975] Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA
modified	[InstanceEdit:110327] Matthews, L, 2004-01-29 18:52:00 [InstanceEdit:111239] Matthews, L, 2004-02-09 03:00:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:2671733] D'Eustachio, P, 2012-11-23 [InstanceEdit:5636004] Orlic-Milacic, Marija, 2014-11-08 [InstanceEdit:5644006] Orlic-Milacic, Marija, 2014-11-19 [InstanceEdit:5651910] Orlic-Milacic, Marija, 2014-11-25 [InstanceEdit:5658589] Orlic-Milacic, Marija, 2014-12-19 [InstanceEdit:5659712] Orlic-Milacic, Marija, 2014-12-22 [InstanceEdit:5674223] Orlic-Milacic, Marija, 2015-02-11 [InstanceEdit:5674537] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:5674541] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:9663707] Orlic-Milacic, Marija, 2019-10-10 [InstanceEdit:9663886] Orlic-Milacic, Marija, 2019-10-16 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Excision of 8-oxoguanine by OGG1 glycosylase
output	[SimpleEntity:110242] 8oxoG [nucleoplasm] [Complex:110195] OGG1:AP-dsDNA [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:110235] OGG1 glycosylase mediated recognition and binding of an 8-oxoguanine opposite to a cytosine [Homo sapiens] [BlackBoxEvent:9656948] OGG1alpha translocates to the nucleus [Homo sapiens]
releaseDate	2004-03-06
reviewed	[InstanceEdit:5673689] Borowiec, James, 2014-12-22 [InstanceEdit:9663702] Vlahopoulos, Spiros, 2019-10-02 [InstanceEdit:9663703] Boldogh, Istvan, 2019-10-08
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358987] R-HSA-110243.3
summation	[Summation:178541] OGG1 acts as an N-glycosylase and a DNA beta-lyase to excise...
(hasEvent)	[Pathway:110331] Cleavage of the damaged purine [Homo sapiens]
(normalReaction)	[FailedReaction:9656250] Defective OGG1 mutants do not excise 8-oxoguanine [Homo sapiens]
(precedingEvent)	[Reaction:110354] Displacement of OGG1 glycosylase by APEX1 at the AP site [Homo sapiens] [Reaction:5649701] NEIL1,NEIL2 displace OGG1 from AP-dsDNA [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777493] Update Tracker - [Reaction:110243] Excision of 8-oxoguanine by OGG1 glycosylase - v71:[modifyText] [_UpdateTracker:9785307] Update Tracker - [Reaction:110243] Excision of 8-oxoguanine by OGG1 glycosylase - v52:[add_removeCatalystActivity, modifyText, removeLiteratureReference] [_UpdateTracker:9785737] Update Tracker - [Reaction:110243] Excision of 8-oxoguanine by OGG1 glycosylase - v51:[addLiteratureReference, modifyText]
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