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Details on Person Cleavage of uracil by MBD4 glycosylase

Class:Id	Reaction:110231
_displayName	Cleavage of uracil by MBD4 glycosylase
_doRelease	TRUE
_timestamp	2015-02-12 18:21:06
authored	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00
catalystActivity	[CatalystActivity:5643991] DNA N-glycosylase activity of MBD4:CpG(U:G)-dsDNA [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:110175] Matthews, L, 2004-01-29 08:00:00
edited	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00 [InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
input	[Complex:110168] MBD4:CpG(U:G)-dsDNA [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:5637552] Investigation of the substrate spectrum of the human mismatch-specific DNA N-glycosylase MED1 (MBD4): fundamental role of the catalytic domain
modified	[InstanceEdit:110327] Matthews, L, 2004-01-29 18:52:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:2671734] D'Eustachio, P, 2012-11-23 [InstanceEdit:5637553] Orlic-Milacic, Marija, 2014-11-10 [InstanceEdit:5644012] Orlic-Milacic, Marija, 2014-11-19 [InstanceEdit:5674223] Orlic-Milacic, Marija, 2015-02-11 [InstanceEdit:5674537] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:5674541] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Cleavage of uracil by MBD4 glycosylase
output	[SimpleEntity:29554] Ura [nucleoplasm] [Complex:110194] MBD4:CpG(AP)-dsDNA [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:110171] MBD4 glycosylase mediated recognition and binding of an uracil opposite to a guanine at CpG sequences [Homo sapiens]
releaseDate	2004-03-06
reviewed	[InstanceEdit:5673689] Borowiec, James, 2014-12-22
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361841] R-HSA-110231.2
summation	[Summation:178553] MBD4 (MED1; methyl-CpG-binding domain protein 4) cleaves ura...
(hasEvent)	[Pathway:110329] Cleavage of the damaged pyrimidine [Homo sapiens]
(precedingEvent)	[Reaction:110353] Displacement of MBD4 glycosylase by APEX1 at the AP site [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9784916] Update Tracker - [Reaction:110231] Cleavage of uracil by MBD4 glycosylase - v52:[add_removeCatalystActivity, modifyText] [_UpdateTracker:9785681] Update Tracker - [Reaction:110231] Cleavage of uracil by MBD4 glycosylase - v51:[addLiteratureReference, modifyText]
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