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Details on Person Cleavage of dihydrouracil by NTHL1 glycosylase

Class:IdReaction:110227
_displayNameCleavage of dihydrouracil by NTHL1 glycosylase
_doReleaseTRUE
_timestamp2015-02-12 18:21:05
authored[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00
catalystActivity[CatalystActivity:5643996] oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity of NTHL1:DHU-dsDNA [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:110175] Matthews, L, 2004-01-29 08:00:00
edited[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00
[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
input[Complex:110181] NTHL1:DHU-dsDNA [nucleoplasm] [Homo sapiens]
literatureReference[LiteratureReference:5637569] Purification and characterization of human NTH1, a homolog of Escherichia coli endonuclease III. Direct identification of Lys-212 as the active nucleophilic residue
[LiteratureReference:5637590] Substrate specificity of the Escherichia coli endonuclease III: excision of thymine- and cytosine-derived lesions in DNA produced by radiation-generated free radicals
modified[InstanceEdit:110327] Matthews, L, 2004-01-29 18:52:00
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:2671733] D'Eustachio, P, 2012-11-23
[InstanceEdit:5637592] Orlic-Milacic, Marija, 2014-11-11
[InstanceEdit:5644008] Orlic-Milacic, Marija, 2014-11-19
[InstanceEdit:5651910] Orlic-Milacic, Marija, 2014-11-25
[InstanceEdit:5674223] Orlic-Milacic, Marija, 2015-02-11
[InstanceEdit:5674537] Orlic-Milacic, Marija, 2015-02-12
[InstanceEdit:5674541] Orlic-Milacic, Marija, 2015-02-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameCleavage of dihydrouracil by NTHL1 glycosylase
output[SimpleEntity:30140] DHU [nucleoplasm]
[Complex:110193] NTHL1:AP-dsDNA [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2004-03-06
reviewed[InstanceEdit:5673689] Borowiec, James, 2014-12-22
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358356] R-HSA-110227.2
summation[Summation:178543] NTHL1 (hNTH1; endonuclease III-like protein 1) acts as a DNA...
(hasEvent)[Pathway:110329] Cleavage of the damaged pyrimidine [Homo sapiens]
(normalReaction)[FailedReaction:9630055] NTHL1 D239Y does not cleave dihydrouracil (DHU) [Homo sapiens]
(precedingEvent)[Reaction:110352] Displacement of NTHL1 glycosylase by APEX1 at the AP site [Homo sapiens]
(updatedInstance)[_UpdateTracker:9785411] Update Tracker - [Reaction:110227] Cleavage of dihydrouracil by NTHL1 glycosylase - v52:[add_removeCatalystActivity, modifyText]
[_UpdateTracker:9785883] Update Tracker - [Reaction:110227] Cleavage of dihydrouracil by NTHL1 glycosylase - v51:[addLiteratureReference, modifyText]
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