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Details on Person NTHL1 glycosylase mediated recognition and binding of dihydrouracil

Class:Id	Reaction:110212
_displayName	NTHL1 glycosylase mediated recognition and binding of dihydrouracil
_doRelease	TRUE
_timestamp	2015-02-12 18:21:10
authored	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:110175] Matthews, L, 2004-01-29 08:00:00
edited	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00 [InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
input	[EntityWithAccessionedSequence:60537] NTHL1 [nucleoplasm] [Homo sapiens] [GenomeEncodedEntity:110180] DHU-dsDNA [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:5637569] Purification and characterization of human NTH1, a homolog of Escherichia coli endonuclease III. Direct identification of Lys-212 as the active nucleophilic residue [LiteratureReference:5637590] Substrate specificity of the Escherichia coli endonuclease III: excision of thymine- and cytosine-derived lesions in DNA produced by radiation-generated free radicals
modified	[InstanceEdit:110327] Matthews, L, 2004-01-29 18:52:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:2671734] D'Eustachio, P, 2012-11-23 [InstanceEdit:5637591] Orlic-Milacic, Marija, 2014-11-11 [InstanceEdit:5651910] Orlic-Milacic, Marija, 2014-11-25 [InstanceEdit:5674223] Orlic-Milacic, Marija, 2015-02-11 [InstanceEdit:5674537] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:5674541] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NTHL1 glycosylase mediated recognition and binding of dihydrouracil
output	[Complex:110181] NTHL1:DHU-dsDNA [nucleoplasm] [Homo sapiens]
releaseDate	2004-03-06
reviewed	[InstanceEdit:5673689] Borowiec, James, 2014-12-22
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359361] R-HSA-110212.2
summation	[Summation:178865] NTHL1 (hNTH1; endonuclease III-like protein 1) recognizes an...
(hasEvent)	[Pathway:110328] Recognition and association of DNA glycosylase with site containing an affected pyrimidine [Homo sapiens]
(normalReaction)	[FailedReaction:9630045] Defective NTHL1 truncation mutants do not bind dihydrouracil (DHU) [Homo sapiens]
(precedingEvent)	[Reaction:110227] Cleavage of dihydrouracil by NTHL1 glycosylase [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9785220] Update Tracker - [Reaction:110212] NTHL1 glycosylase mediated recognition and binding of dihydrouracil - v52:[modifyText] [_UpdateTracker:9785619] Update Tracker - [Reaction:110212] NTHL1 glycosylase mediated recognition and binding of dihydrouracil - v51:[addLiteratureReference, modifyText]
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