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Details on Person MBD4 glycosylase mediated recognition and binding of a thymine opposite to a guanine at CpG sequences

Class:Id	Reaction:110172
_displayName	MBD4 glycosylase mediated recognition and binding of a thymine opposite to a guanine at CpG sequences
_doRelease	TRUE
_timestamp	2015-02-12 18:21:09
authored	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:110148] Matthews, L, 2004-01-28 20:00:00
edited	[InstanceEdit:110568] Matthews, L, 2004-02-03 00:30:00 [InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
input	[GenomeEncodedEntity:110169] CpG(T:G)-dsDNA [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3006633] MBD4 [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:5637543] Biphasic kinetics of the human DNA repair protein MED1 (MBD4), a mismatch-specific DNA N-glycosylase [LiteratureReference:5637547] Mismatch repair in methylated DNA. Structure and activity of the mismatch-specific thymine glycosylase domain of methyl-CpG-binding protein MBD4 [LiteratureReference:5637542] Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA
modified	[InstanceEdit:110327] Matthews, L, 2004-01-29 18:52:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:2671734] D'Eustachio, P, 2012-11-23 [InstanceEdit:3006634] Jupe, S, 2013-01-31 [InstanceEdit:5637549] Orlic-Milacic, Marija, 2014-11-10 [InstanceEdit:5674223] Orlic-Milacic, Marija, 2015-02-11 [InstanceEdit:5674537] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:5674541] Orlic-Milacic, Marija, 2015-02-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MBD4 glycosylase mediated recognition and binding of a thymine opposite to a guanine at CpG sequences
output	[Complex:110170] MBD4:CpG(T:G)-dsDNA [nucleoplasm] [Homo sapiens]
releaseDate	2004-03-06
reviewed	[InstanceEdit:5673689] Borowiec, James, 2014-12-22
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360771] R-HSA-110172.2
summation	[Summation:178946] MBD4 (MED1; methyl-CpG-binding domain protein 4) recognizes ...
(hasEvent)	[Pathway:110328] Recognition and association of DNA glycosylase with site containing an affected pyrimidine [Homo sapiens]
(precedingEvent)	[Reaction:110232] Cleavage of thymine by MBD4 glycosylase [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9785014] Update Tracker - [Reaction:110172] MBD4 glycosylase mediated recognition and binding of a thymine opposite to a guanine at CpG sequences - v52:[modifyText] [_UpdateTracker:9785705] Update Tracker - [Reaction:110172] MBD4 glycosylase mediated recognition and binding of a thymine opposite to a guanine at CpG sequences - v51:[addLiteratureReference, modifyText] [_UpdateTracker:9787593] Update Tracker - [Reaction:110172] MBD4 glycosylase mediated recognition and binding of a thymine opposite to a guanine at CpG sequences - v44:[add_removeInput]
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