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Details on Person Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor.

Class:Id	LiteratureReference:110012
_displayName	Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor.
_timestamp	2011-07-22 15:51:41
author	[Person:111013] Wick, KR [Person:111014] Werner, ED [Person:111015] Langlais, P [Person:111016] Ramos, FJ [Person:111017] Dong, LQ [Person:111018] Shoelson, SE [Person:110770] Liu, F
journal	J Biol Chem
modified	[InstanceEdit:1458674] D'Eustachio, P, 2011-07-22
pages	8460-7
pubMedIdentifier	12493740
title	Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor.
volume	278
year	2003
(literatureReference)	[RegulationReference:9642069] Negative regulation by 'GRB10:INSR [plasma membrane]' Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor. [Reaction:110011] Binding of Grb10 to the insulin receptor [Homo sapiens]
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No pathways have been reviewed or authored by Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor. (110012)