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Details on Person cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]

Class:Id	Reaction:109903
_displayName	cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]
_doRelease	TRUE
_timestamp	2025-12-16 18:01:37
catalystActivity	[CatalystActivity:109900] nucleoside kinase activity of UCK2 tetramer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643215] nucleoside kinase activity of UCK2 tetramer [cytosol] Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:109881] D'Eustachio, P, 2004-01-21 17:18:00
crossReference	[DatabaseIdentifier:9976243] RHEA:24675 [DatabaseIdentifier:9976249] RHEA:16826
input	[DefinedSet:500759] Cyt-Rib, Ura-Rib [cytosol] [SimpleEntity:113592] ATP [cytosol]
internalReviewed	[InstanceEdit:9977060] D'Eustachio, Peter, 2025-12-16
literatureReference	[LiteratureReference:109887] Uridine kinase activities and pyrimidine nucleoside phosphorylation in fluoropyrimidine-sensitive and -resistant cell lines of the Novikoff hepatoma [LiteratureReference:500798] Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase [LiteratureReference:109895] Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases [LiteratureReference:109899] Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases
modified	[InstanceEdit:109905] D'Eustachio, P, 2004-01-21 17:35:00 [InstanceEdit:109918] D'Eustachio, P, 2004-01-22 15:13:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:179974] D'Eustachio, P, 2006-05-11 22:54:01 [InstanceEdit:500796] D'Eustachio, P, 2010-02-05 [InstanceEdit:500809] D'Eustachio, P, 2010-02-05 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9976255] D'Eustachio, Peter, 2025-12-09 [InstanceEdit:9977061] D'Eustachio, Peter, 2025-12-16 [InstanceEdit:9977063] D'Eustachio, Peter, 2025-12-16
name	cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] cytidine + ATP => CMP + ADP + H(+) uridine + ATP => UMP + ADP + H(+)
output	[DefinedSet:500761] CMP, UMP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:70106] H+ [cytosol]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2004-07-06
reviewed	[InstanceEdit:9977064] D'Eustachio, Peter, 2025-12-16
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359057] R-HSA-109903.5
structureModified	[InstanceEdit:9976255] D'Eustachio, Peter, 2025-12-09
summation	[Summation:178597] Cytosolic uridine-cytidine kinase 2 (UCK2) catalyzes the rea...
(hasEvent)	[Pathway:73614] Pyrimidine salvage [Homo sapiens]
(replacementInstances)	[_Deleted:500804] Deletion of instances: 109904, 109901
(updatedInstance)	[_UpdateTracker:9790893] Update Tracker - [Reaction:109903] cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText] [_UpdateTracker:9984644] Update Tracker - [Reaction:109903] cytidine or uridine + ATP => CMP or UMP + ADP [UCK2] - v96:[removeOutput]
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