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Details on Person Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2

Class:Id	Reaction:109864
_displayName	Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2
_doRelease	TRUE
_timestamp	2017-04-05 15:28:34
authored	[InstanceEdit:158672] Charalambous, M, 2005-02-04 06:50:22
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:112400] Charalambous, M, 2004-04-29 09:21:24
edited	[InstanceEdit:165100] Schmidt, EE, 0000-00-00 00:00:00
figure	[Figure:158659] /figures/Diss_MEK_ERK.jpg
input	[Complex:109854] p-S,T-MAP2K2:p-T,Y-MAPK1 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:208207] Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues
modified	[InstanceEdit:110001] Schmidt, EE, 2004-01-23 05:11:12 [InstanceEdit:112397] Schmidt, EE, 2004-04-29 09:21:20 [InstanceEdit:156504] Schmidt, EE, 2004-11-17 16:02:05 [InstanceEdit:158660] Schmidt, EE, 2005-02-04 11:34:53 [InstanceEdit:163616] Schmidt, EE, 2005-05-03 09:53:07 [InstanceEdit:188337] Jassal, Bijay, 2006-10-10 [InstanceEdit:188624] Jassal, Bijay, 2006-10-19 [InstanceEdit:196906] Gopinathrao, G, 2007-04-25 14:54:44 [InstanceEdit:447003] D'Eustachio, P, 2009-11-19 [InstanceEdit:1008271] Shamovsky, V, 2010-11-10 [InstanceEdit:1097353] Matthews, L, 2010-11-30 [InstanceEdit:5684237] Shamovsky, Veronica, 2015-03-20 [InstanceEdit:8984379] Duenas, Corina, 2017-04-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2
output	[EntityWithAccessionedSequence:109853] p-T185,Y187-MAPK1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:109848] p-S,T-MAP2K2 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:109862] MAP2K2 phosphorylates MAPK1 [Homo sapiens] [Reaction:109858] MAP2K2 binds MAPK1 [Homo sapiens]
releaseDate	2010-12-14
reviewed	[InstanceEdit:1047549] Gillespie, ME, 2010-11-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104067] R-HSA-109864.3
summation	[Summation:158663] MAP2K2 (MEK2) dissociates from phosphorylated MAPK1 (ERK2), ...
(hasEvent)	[Pathway:112411] MAPK1 (ERK2) activation [Homo sapiens]
(inferredFrom)	[Reaction:451505] Dissociation of phospho ERK2 :phospho MEK2 complex [Gallus gallus]
(precedingEvent)	[BlackBoxEvent:443795] ERK1/2 induce DUSP1/4 activation [Homo sapiens] [Reaction:5674385] p-T,Y MAPKs dimerize [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781181] Update Tracker - [Reaction:109864] Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 - v61:[addLiteratureReference, modifyText] [_UpdateTracker:9784554] Update Tracker - [Reaction:109864] Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 - v53:[modifyText]
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