Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person (Controversial - not included in public release.) Crk:SOS binds IRS-P

Class:IdReaction:109826
_displayName(Controversial - not included in public release.) Crk:SOS binds IRS-P
_doReleaseFALSE
_timestamp2016-12-01 00:31:28
authored[InstanceEdit:157820] Charalambous, M, 2005-01-07 11:17:43
compartment[Compartment:947587] cytoplasmic side of plasma membrane
created[InstanceEdit:112400] Charalambous, M, 2004-04-29 09:21:24
edited[InstanceEdit:165100] Schmidt, EE, 0000-00-00 00:00:00
figure[Figure:157809]
input[Complex:109810] Crk:SOS [cytosol] [Homo sapiens]
[DefinedSet:112322] p-Y-IRS1,p-Y-IRS2 [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:110025] Interactions between Src homology SH2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor.
[LiteratureReference:112325] The proto-oncogene product c-Crk associates with insulin receptor substrate-1 and 4PS. Modulation by insulin growth factor-I (IGF) and enhanced IGF-I signaling.
modified[InstanceEdit:110001] Schmidt, EE, 2004-01-23 05:11:12
[InstanceEdit:112321] Schmidt, EE, 2004-04-23 05:08:43
[InstanceEdit:112397] Schmidt, EE, 2004-04-29 09:21:20
[InstanceEdit:157832] Schmidt, EE, 2005-01-07 14:20:30
[InstanceEdit:158674] Schmidt, EE, 2005-02-04 12:38:51
[InstanceEdit:163333] Schmidt, EE, 2005-04-27 13:59:26
[InstanceEdit:163616] Schmidt, EE, 2005-05-03 09:53:07
[InstanceEdit:8879177] Wu, G, 2016-07-15
[InstanceEdit:8949915] D'Eustachio, Peter, 2016-12-01
name(Controversial - not included in public release.) Crk:SOS binds IRS-P
output[Complex:109811] Crk:SOS:IRS-P [cytosol] [Homo sapiens]
precedingEvent
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:8880973] R-HSA-109826.1
summation[Summation:157826] Controversial - not included in published version. Inactive ...
(hasEvent)[Pathway:162546] DNR reactions [Homo sapiens]
(precedingEvent)[Reaction:109825] (Controversial - not included in public release.) SOS mediated nucleotide exchange of RAS (IRS, Crk) [Homo sapiens]
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No pathways have been reviewed or authored by (Controversial - not included in public release.) Crk:SOS binds IRS-P (109826)