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Details on Person (Controversial - not included in public release.) SOS mediated nucleotide exchange of RAS (IRS, Crk)

Class:Id	Reaction:109825
_displayName	(Controversial - not included in public release.) SOS mediated nucleotide exchange of RAS (IRS, Crk)
_doRelease	FALSE
_timestamp	2016-12-01 00:31:29
catalystActivity	[CatalystActivity:109824] guanyl-nucleotide exchange factor activity of Crk:SOS:IRS-P [cytosol]
compartment	[Compartment:947587] cytoplasmic side of plasma membrane
created	[InstanceEdit:112400] Charalambous, M, 2004-04-29 09:21:24
figure	[Figure:157823] /figures/SOS_ras_IRS_Crk.jpg
input	[Complex:109796] p21 RAS:GDP [plasma membrane] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
literatureReference	[LiteratureReference:110025] Interactions between Src homology SH2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor.
modified	[InstanceEdit:110001] Schmidt, EE, 2004-01-23 05:11:12 [InstanceEdit:112397] Schmidt, EE, 2004-04-29 09:21:20 [InstanceEdit:157832] Schmidt, EE, 2005-01-07 14:20:30 [InstanceEdit:163333] Schmidt, EE, 2005-04-27 13:59:26 [InstanceEdit:163616] Schmidt, EE, 2005-05-03 09:53:07 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8949915] D'Eustachio, Peter, 2016-12-01
name	(Controversial - not included in public release.) SOS mediated nucleotide exchange of RAS (IRS, Crk)
output	[Complex:109783] p21 RAS:GTP [plasma membrane] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol]
precedingEvent	[Reaction:109826] (Controversial - not included in public release.) Crk:SOS binds IRS-P [Homo sapiens] [Reaction:109814] Crk binds SOS [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8899592] R-HSA-109825.1
(precedingEvent)	[Reaction:109827] SOS phosphorylation and dissociation (IRS, Crk) [Homo sapiens]
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No pathways have been reviewed or authored by (Controversial - not included in public release.) SOS mediated nucleotide exchange of RAS (IRS, Crk) (109825)