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Details on Person GRB2-1 binds SOS1

Class:Id	Reaction:109813
_displayName	GRB2-1 binds SOS1
_doRelease	TRUE
_timestamp	2015-03-27 11:29:11
authored	[InstanceEdit:157820] Charalambous, M, 2005-01-07 11:17:43
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:112400] Charalambous, M, 2004-04-29 09:21:24
edited	[InstanceEdit:165100] Schmidt, EE, 0000-00-00 00:00:00 [InstanceEdit:1529121] Orlic-Milacic, Marija, 2011-08-25
figure	[Figure:157824] /figures/Grb2_SOS.jpg
input	[EntityWithAccessionedSequence:74686] GRB2-1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:64847] SOS1 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:110024] Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling.
modified	[InstanceEdit:110001] Schmidt, EE, 2004-01-23 05:11:12 [InstanceEdit:112397] Schmidt, EE, 2004-04-29 09:21:20 [InstanceEdit:157832] Schmidt, EE, 2005-01-07 14:20:30 [InstanceEdit:163616] Schmidt, EE, 2005-05-03 09:53:07 [InstanceEdit:180389] D'Eustachio, P, 2006-05-18 18:57:06 [InstanceEdit:180389] D'Eustachio, P, 2006-05-18 18:57:06 [InstanceEdit:180389] D'Eustachio, P, 2006-05-18 18:57:06 [InstanceEdit:180389] D'Eustachio, P, 2006-05-18 18:57:06 [InstanceEdit:180389] D'Eustachio, P, 2006-05-18 18:57:06 [InstanceEdit:180395] D'Eustachio, P, 2006-05-18 19:19:16 [InstanceEdit:188418] Jassal, B, 2006-10-12 13:41:50 [InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00 [InstanceEdit:188444] Jassal, Bijay, 2006-10-13 [InstanceEdit:189370] Gopinathrao, G, 2006-11-06 22:11:18 [InstanceEdit:192578] Gopinathrao, G, 2007-02-06 21:04:41 [InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31 [InstanceEdit:212475] Jassal, Bijay, 2008-02-12 [InstanceEdit:215260] Gopinathrao, G, 2008-02-28 03:55:01 [InstanceEdit:1566986] Orlic-Milacic, Marija, 2011-09-06 [InstanceEdit:1583065] Orlic-Milacic, Marija, 2011-09-07 [InstanceEdit:5624357] Jupe, Steve, 2014-09-25 [InstanceEdit:5685364] Jupe, Steve, 2015-03-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GRB2-1 binds SOS1
output	[Complex:109797] GRB2-1:SOS1 [cytosol] [Homo sapiens]
releaseDate	2008-03-12
reviewed	[InstanceEdit:212476] Heldin, CH, 2008-02-12 09:44:02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359134] R-HSA-109813.2
summation	[Summation:157813] In the cytoplasm of unstimulated cells, SOS1 is found in a c...
(hasEvent)	[Pathway:74751] Insulin receptor signalling cascade [Homo sapiens] [Pathway:179812] GRB2 events in EGFR signaling [Homo sapiens]
(precedingEvent)	[Reaction:74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 [Homo sapiens] [Reaction:74746] GRB2-1:SOS1 binds p-Y427-SHC1 [Homo sapiens] [Reaction:177936] GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR [Homo sapiens] [Reaction:177943] GRB2:SOS1 complex binds to EGF:EGFR complex [Homo sapiens] [Reaction:453111] Phosphorylated SHC recruits GRB2:SOS1 [Homo sapiens] [Reaction:5685366] GRB2-1:SOS1 binds p-Y-SHC [Homo sapiens] [Reaction:5686073] GRB2-1:SOS1 binds p-3Y-SHC1 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9789410] Update Tracker - [Reaction:109813] GRB2-1 binds SOS1 - v38:[modifyText]
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