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Details on Person GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS

Class:IdReaction:109807
_displayNameGRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
_doReleaseTRUE
_timestamp2015-03-31 16:41:25
authored[InstanceEdit:157820] Charalambous, M, 2005-01-07 11:17:43
catalystActivity[CatalystActivity:109806] guanyl-nucleotide exchange factor activity of GRB2-1:SOS1:p-Y427-SHC1 [cytosol]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:112400] Charalambous, M, 2004-04-29 09:21:24
edited[InstanceEdit:165100] Schmidt, EE, 0000-00-00 00:00:00
figure[Figure:157816] /figures/SOS_ras_SHC.jpg
inferredFrom
input[Complex:109796] p21 RAS:GDP [plasma membrane] [Homo sapiens]
[SimpleEntity:29438] GTP [cytosol]
literatureReference[LiteratureReference:187761] The structural basis of the activation of Ras by Sos
modified[InstanceEdit:110001] Schmidt, EE, 2004-01-23 05:11:12
[InstanceEdit:112335] Schmidt, EE, 2004-04-27 10:09:34
[InstanceEdit:112397] Schmidt, EE, 2004-04-29 09:21:20
[InstanceEdit:157832] Schmidt, EE, 2005-01-07 14:20:30
[InstanceEdit:163616] Schmidt, EE, 2005-05-03 09:53:07
[InstanceEdit:169286] Jassal, Bijay, 2005-11-28
[InstanceEdit:187730] Jassal, Bijay, 2006-09-21
[InstanceEdit:188337] Jassal, Bijay, 2006-10-10
[InstanceEdit:188624] Jassal, Bijay, 2006-10-19
[InstanceEdit:189835] Jassal, Bijay, 2006-12-07
[InstanceEdit:196906] Gopinathrao, G, 2007-04-25 14:54:44
[InstanceEdit:204298] Jassal, Bijay, 2007-11-28
[InstanceEdit:453095] Jupe, S, 2010-01-18
[InstanceEdit:1806830] Jassal, Bijay, 2011-10-24
[InstanceEdit:5255454] D'Eustachio, Peter, 2014-02-06
[InstanceEdit:5685348] Jupe, Steve, 2015-03-27
[InstanceEdit:5686058] Jupe, Steve, 2015-03-31
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameGRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS
output[Complex:109783] p21 RAS:GTP [plasma membrane] [Homo sapiens]
[SimpleEntity:29420] GDP [cytosol]
precedingEvent
releaseDate2007-12-11
reviewed[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359798] R-HSA-109807.2
summation[Summation:157817] SOS promotes the formation of GTP-bound RAS, thus activating...
(hasEvent)[Pathway:74751] Insulin receptor signalling cascade [Homo sapiens]
(precedingEvent)[Reaction:170986] Ral-GDS binds to Ras-GTP [Homo sapiens]
(updatedInstance)[_UpdateTracker:9784564] Update Tracker - [Reaction:109807] GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS - v53:[modifyText]
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No pathways have been reviewed or authored by GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS (109807)
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