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Details on Person GRB2-1:SOS1 [cytosol]

Class:IdComplex:109797
_displayNameGRB2-1:SOS1 [cytosol]
_timestamp2017-11-14 13:00:10
compartment[Compartment:70101] cytosol
created[InstanceEdit:109781] Schmidt, EE, 2004-01-21 04:32:59
hasComponent
literatureReference[LiteratureReference:9029032] Gab1 transduces PI3K-mediated erythropoietin signals to the Erk pathway and regulates erythropoietin-dependent proliferation and survival of erythroid cells
[LiteratureReference:179827] Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
modified[InstanceEdit:508240] Jupe, S, 2010-02-11
[InstanceEdit:5685364] Jupe, Steve, 2015-03-27
[InstanceEdit:8876264] Orlic-Milacic, Marija, 2016-06-10
[InstanceEdit:9029143] May, Bruce, 2017-11-14
nameGRB2-1:SOS1
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:365515] R-HSA-109797.3
(activeUnit)[CatalystActivity:8851826] guanyl-nucleotide exchange factor activity of HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane]
[CatalystActivity:9634417] guanyl-nucleotide exchange factor activity of p-ERBB2 homodimer:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane]
[CatalystActivity:9672166] guanyl-nucleotide exchange factor activity of p-11Y PDGFRA extracellular domain dimers:GRB2:SOS1 [endoplasmic reticulum membrane]
(hasComponent)[Complex:109798] GRB2-1:SOS1:p-Y427-SHC1 [cytosol] [Homo sapiens]
[Complex:109800] GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] [Homo sapiens]
[Complex:179820] EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] [Homo sapiens]
[Complex:180331] EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] [Homo sapiens]
[Complex:186827] PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] [Homo sapiens]
[Complex:205202] GRB2:SOS1:p-KIT complex [plasma membrane] [Homo sapiens]
[Complex:453093] IL2:IL2R trimer p-(Y338)-beta subunit:p-JAK1:JAK3:p-SHC:GRB2:SOS [plasma membrane] [Homo sapiens]
[Complex:532252] FGFR1:GRB2:SOS1:p-SHC:SRC [plasma membrane] [Homo sapiens]
[Complex:912536] IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:SOS1 [plasma membrane] [Homo sapiens]
[Complex:921157] Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] [Homo sapiens]
List all 87 refering instances
(hasMember)[DefinedSet:9029090] GRB2-1:SOS1,VAV1 [cytosol] [Homo sapiens]
(input)[Reaction:74736] GRB2-1:SOS1 binds p-IRS1,p-IRS2 [Homo sapiens]
[Reaction:74746] GRB2-1:SOS1 binds p-Y427-SHC1 [Homo sapiens]
[Reaction:167210] Phosphorylated Shc binds with the Grb2:SOS complex [Homo sapiens]
[Reaction:177936] GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR [Homo sapiens]
[Reaction:177943] GRB2:SOS1 complex binds to EGF:EGFR complex [Homo sapiens]
[Reaction:186826] GRB2:SOS1 complex binds to the active receptor [Homo sapiens]
[BlackBoxEvent:190402] Grb2:Sos associates with FGFR, p-Shc, Src [Homo sapiens]
[Reaction:205286] GRB2:SOS interacts with p-KIT [Homo sapiens]
[Reaction:453111] Phosphorylated SHC recruits GRB2:SOS1 [Homo sapiens]
[Reaction:1225950] Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants [Homo sapiens]
List all 54 refering instances
(output)[Reaction:109813] GRB2-1 binds SOS1 [Homo sapiens]
[Reaction:9733331] CSF1 dimer,IL34 dimer:p-Y561-CSF1R:GRB2:SOS1 dissociates yielding CSF1 dimer,IL34 dimer:p-Y561-CSF1R:SFK and GRB2:SOS1 [Homo sapiens]
[Reaction:9846384] GOCAM GRB2-1 binds SOS1 [Homo sapiens]
(physicalEntity)[CatalystActivity:9851158] transmembrane receptor protein tyrosine kinase adaptor activity of GRB2-1:SOS1 [cytosol]
[CatalystActivity:9851163] protein-macromolecule adaptor activity of GRB2-1:SOS1 [cytosol]
(updatedInstance)[_UpdateTracker:9868684] Update Tracker - [Complex:109797] GRB2-1:SOS1 [cytosol] - v32:[modifyName]
[_UpdateTracker:9892557] Update Tracker - [Complex:109797] GRB2-1:SOS1 [cytosol] - v53:[modifyName]
[_UpdateTracker:9898136] Update Tracker - [Complex:109797] GRB2-1:SOS1 [cytosol] - v63:[addLiteratureReference]
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No pathways have been reviewed or authored by GRB2-1:SOS1 [cytosol] (109797)
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