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Details on Person p21 RAS:GTP [plasma membrane]

Class:IdComplex:109783
_displayNamep21 RAS:GTP [plasma membrane]
_timestamp2019-08-12 14:51:24
compartment[Compartment:876] plasma membrane
created[InstanceEdit:109781] Schmidt, EE, 2004-01-21 04:32:59
hasComponent
modified[InstanceEdit:1998742] Orlic-Milacic, Marija, 2011-11-19
[InstanceEdit:2213009] Matthews, L, 2012-04-27
[InstanceEdit:9658204] Rothfels, Karen, 2019-08-12
namep21 RAS:GTP
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:369610] R-HSA-109783.2
(hasComponent)[Complex:109788] RAS:RAF [plasma membrane] [Homo sapiens]
[Complex:109793] 14-3-3:p-S259,Y340,Y341,S621-RAF1:RAS:GTP [plasma membrane] [Homo sapiens]
[Complex:171020] Ras-GTP:RalGDS complex [plasma membrane] [Homo sapiens]
[Complex:5218802] RASA1:p21 RAS:GTP:SPG [plasma membrane] [Homo sapiens]
[Complex:5607706] p-S259,S338,Y340,Y341,S621-RAF1:RAS:GTP:14-3-3 [plasma membrane] [Homo sapiens]
[Complex:5624470] p21 RAS:GTP:p-S338-RAF1 [plasma membrane] [Homo sapiens]
[Complex:5624477] p21 RAS:GTP:p-S338,Y340,Y341-RAF1 [plasma membrane] [Homo sapiens]
[Complex:5624478] p21 RAS:GTP:RAF1 [plasma membrane] [Homo sapiens]
[Complex:5658227] p21 RAS:GTP:RAS GAPs [plasma membrane] [Homo sapiens]
[Complex:5672712] p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] [Homo sapiens]
List all 23 refering instances
(input)[Reaction:170986] Ral-GDS binds to Ras-GTP [Homo sapiens]
[Reaction:5624494] RAF1 binds p21 RAS:GTP [Homo sapiens]
[Reaction:5658435] RAS GAPs bind RAS:GTP [Homo sapiens]
[Reaction:5672950] "Activator" RAF:YWHAB dimer binds RAS:GTP [Homo sapiens]
[Reaction:5674018] BRAP binds RAS:GTP [Homo sapiens]
[Reaction:8981355] RASA1 binds RAS:GTP [Homo sapiens]
[Reaction:9649736] RAS intrinsic GTPase activity hydrolyzes GTP to GDP [Homo sapiens]
[Reaction:9658253] RAS:GTP binds PI3K [Homo sapiens]
(normalEntity)[EntityFunctionalStatus:6802836] loss_of_function of RAS mutants:GTP [plasma membrane]
[EntityFunctionalStatus:6802863] gain_of_function of RAS mutants:GTP [plasma membrane]
[EntityFunctionalStatus:9649911] loss_of_function of RAS GTPase mutants:GTP [plasma membrane]
[EntityFunctionalStatus:9651308] loss_of_function of RAS GAP mutants:GTP [plasma membrane]
(output)[Reaction:109807] GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS [Homo sapiens]
[Reaction:109817] GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS [Homo sapiens]
[Reaction:109825] (Controversial - not included in public release.) SOS mediated nucleotide exchange of RAS (IRS, Crk) [Homo sapiens]
[Reaction:167216] SOS-mediated nucleotide exchange on Ras, activating it [Homo sapiens]
[Reaction:177938] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) [Homo sapiens]
[Reaction:177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) [Homo sapiens]
[Reaction:186834] SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) [Homo sapiens]
[Reaction:210977] Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) [Homo sapiens]
[Reaction:354152] AlphaIIbbeta3 mediated nucleotide exchange of RAS (SHC) [Homo sapiens]
[Reaction:392054] NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras [Homo sapiens]
List all 68 refering instances
(physicalEntity)[CatalystActivity:9649728] GTPase activity of p21 RAS:GTP [plasma membrane]
(updatedInstance)[_UpdateTracker:9871337] Update Tracker - [Complex:109783] p21 RAS:GTP [plasma membrane] - v39:[addCompartment]
[_UpdateTracker:9872152] Update Tracker - [Complex:109783] p21 RAS:GTP [plasma membrane] - v41:[removeCompartment]
[_UpdateTracker:9892340] Update Tracker - [Complex:109783] p21 RAS:GTP [plasma membrane] - v53:[updateContainedComponent]
[_UpdateTracker:9900805] Update Tracker - [Complex:109783] p21 RAS:GTP [plasma membrane] - v70:[add_removeHasComponent]
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No pathways have been reviewed or authored by p21 RAS:GTP [plasma membrane] (109783)
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