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Details on Person PDPK1 phosphorylates AKT2

Class:IdReaction:109702
_displayNamePDPK1 phosphorylates AKT2
_doReleaseTRUE
_timestamp2016-11-10 00:56:03
catalystActivity[CatalystActivity:162381] protein serine/threonine kinase activity of PDPK1:PIP3 [plasma membrane]
catalystActivityReference[CatalystActivityReference:9643668] protein serine/threonine kinase activity of PDPK1:PIP3 [plasma membrane] Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:109694] de Bono, B, 2004-01-20 06:18:07
input[Complex:109696] AKT2:PIP3 [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
literatureReference[LiteratureReference:162388] Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
[LiteratureReference:162378] Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B
[LiteratureReference:5686064] Activation of a GST-tagged AKT2/PKBbeta
modified[InstanceEdit:162394] de Bono, B, 2005-03-24 12:05:55
[InstanceEdit:164720] Jassal, Bijay, 2005-06-16
[InstanceEdit:164887] de Bono, B, 2005-07-13 13:58:17
[InstanceEdit:443394] Jupe, S, 2009-10-05
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:5252137] D'Eustachio, Peter, 2014-02-05
[InstanceEdit:5686058] Jupe, Steve, 2015-03-31
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePDPK1 phosphorylates AKT2
Phosphorylation of PKB by PDK1
output[Complex:162387] p-T309,S474-AKT2:PIP3 [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2005-09-26
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361926] R-HSA-109702.4
summation[Summation:179070] Two specific sites in AKT2, one in the kinase domain (Thr-30...
(hasEvent)[Pathway:165158] Activation of AKT2 [Homo sapiens]
(precedingEvent)[Reaction:162363] p-T309,S474-AKT2:PIP3 phosphorylates PDE3B [Homo sapiens]
[BlackBoxEvent:1445144] p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) [Homo sapiens]
[Reaction:1449597] p-AKT2 phosphorylates Myosin 5A [Homo sapiens]
[Reaction:1458463] p-AKT2 phosphorylates RGC2 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9784553] Update Tracker - [Reaction:109702] PDPK1 phosphorylates AKT2 - v53:[addLiteratureReference, modifyText]
[_UpdateTracker:9791243] Update Tracker - [Reaction:109702] PDPK1 phosphorylates AKT2 - v31:[removeLiteratureReference]
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