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Details on Person AKT2 binds PIP3

Class:Id	Reaction:109700
_displayName	AKT2 binds PIP3
_doRelease	TRUE
_timestamp	2017-11-22 15:49:45
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:109694] de Bono, B, 2004-01-20 06:18:07
input	[Complex:162401] AKT2:THEM4,TRIB3 [cytosol] [Homo sapiens] [SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane]
literatureReference	[LiteratureReference:199452] TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver [LiteratureReference:199446] Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane [LiteratureReference:162409] Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation [LiteratureReference:162390] Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B [LiteratureReference:9028154] AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells
modified	[InstanceEdit:162406] de Bono, B, 2005-03-24 12:06:50 [InstanceEdit:164886] de Bono, B, 2005-07-13 13:57:58 [InstanceEdit:2648974] D'Eustachio, P, 2012-11-21 [InstanceEdit:5686055] Jupe, Steve, 2015-03-31 [InstanceEdit:8940176] D'Eustachio, Peter, 2016-09-23 [InstanceEdit:8940178] D'Eustachio, Peter, 2016-09-23 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9021621] Jupe, Steve, 2017-09-19 [InstanceEdit:9028159] Jupe, Steve, 2017-11-06 [InstanceEdit:9029763] Rothfels, Karen, 2017-11-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AKT2 binds PIP3 PKB attachment to plasma membrane
output	[Complex:109696] AKT2:PIP3 [plasma membrane] [Homo sapiens] [DefinedSet:162414] THEM4,TRIB3 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 [Homo sapiens] [Reaction:188002] Rab5-mediated recruitment of class III PI3K to TLR9 [Homo sapiens] [Reaction:190929] Activated FGFR binds PI3K [Homo sapiens] [Reaction:74737] p-Y-IRS1,p-Y-IRS2 bind PI3K [Homo sapiens] [Reaction:9607224] Active FLT3:GRB2:p-Y-GAB2 binds PIK3R1 [Homo sapiens]
releaseDate	2005-09-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359483] R-HSA-109700.5
summation	[Summation:199427] The phosphorylation of membrane-recruited AKT at threonine a...
(hasEvent)	[Pathway:165158] Activation of AKT2 [Homo sapiens]
(precedingEvent)	[Reaction:109702] PDPK1 phosphorylates AKT2 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780117] Update Tracker - [Reaction:109700] AKT2 binds PIP3 - v64:[add_removeSummation] [_UpdateTracker:9780355] Update Tracker - [Reaction:109700] AKT2 binds PIP3 - v63:[addLiteratureReference, add_removeInput] [_UpdateTracker:9782401] Update Tracker - [Reaction:109700] AKT2 binds PIP3 - v59:[add_removeLiteratureReference]
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