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Details on Person PI3K-containing complexes phosphorylate PIP2 to PIP3

Class:Id	Reaction:109699
_displayName	PI3K-containing complexes phosphorylate PIP2 to PIP3
_doRelease	TRUE
_timestamp	2018-05-02 10:01:48
authored	[InstanceEdit:190908] de Bono, B, 2007-01-10 10:27:18
catalystActivity	[CatalystActivity:162417] 1-phosphatidylinositol-3-kinase activity of PI3K-containing complexes [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:74700] endosome membrane
created	[InstanceEdit:109694] de Bono, B, 2004-01-20 06:18:07
edited	[InstanceEdit:500337] Jupe, S, 2010-02-03
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:179856] PI(4,5)P2 [plasma membrane]
literatureReference	[LiteratureReference:2326869] Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers [LiteratureReference:2326868] Insulin-like growth factor induces phosphorylation of immunoreactive insulin receptor substrate and its association with phosphatidylinositol-3 kinase in human thymocytes [LiteratureReference:2327862] A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane [LiteratureReference:2327861] Dynamics of the phosphoinositide 3-kinase p110? interaction with p85? and membranes reveals aspects of regulation distinct from p110? [LiteratureReference:202402] The role of PI3K in immune cells [LiteratureReference:9029754] The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
modified	[InstanceEdit:112397] Schmidt, EE, 2004-04-29 09:21:20 [InstanceEdit:141752] Joshi-Tope, G, 2004-10-04 01:02:45 [InstanceEdit:162416] de Bono, B, 2005-03-24 12:10:10 [InstanceEdit:164720] Jassal, Bijay, 2005-06-16 [InstanceEdit:164884] de Bono, B, 2005-07-13 13:57:33 [InstanceEdit:165707] de Bono, B, 2005-08-09 10:42:34 [InstanceEdit:165738] de Bono, B, 2005-08-09 12:50:20 [InstanceEdit:190930] de Bono, B, 2007-01-10 15:33:14 [InstanceEdit:192578] Gopinathrao, G, 2007-02-06 21:04:41 [InstanceEdit:193315] Gopinathrao, G, 2007-02-14 10:37:06 [InstanceEdit:193359] Gopinathrao, G, 2007-02-16 20:25:31 [InstanceEdit:500344] Jupe, S, 2010-02-03 [InstanceEdit:532227] Jupe, S, 2010-02-26 [InstanceEdit:1317419] D'Eustachio, P, 2011-06-01 [InstanceEdit:1380730] Rothfels, K, 2011-07-06 [InstanceEdit:2851311] Jupe, S, 2012-12-13 [InstanceEdit:5252137] D'Eustachio, Peter, 2014-02-05 [InstanceEdit:5686067] Jupe, Steve, 2015-03-31 [InstanceEdit:9021622] Jupe, Steve, 2017-09-19 [InstanceEdit:9029766] Rothfels, Karen, 2017-11-22 [InstanceEdit:9029771] Rothfels, Karen, 2017-11-22 [InstanceEdit:9029780] Rothfels, Karen, 2017-11-22 [InstanceEdit:9607233] Varusai, Thawfeek, 2018-05-01 [InstanceEdit:9607237] Varusai, Thawfeek, 2018-05-01 [InstanceEdit:9607238] Varusai, Thawfeek, 2018-05-01 [InstanceEdit:9607299] Varusai, Thawfeek, 2018-05-02 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PI3K-containing complexes phosphorylate PIP2 to PIP3
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:188002] Rab5-mediated recruitment of class III PI3K to TLR9 [Homo sapiens] [Reaction:187895] Engulfed CpG DNA binds to endosomal C-ter TLR9 [Homo sapiens] [Reaction:190929] Activated FGFR binds PI3K [Homo sapiens] [Reaction:74737] p-Y-IRS1,p-Y-IRS2 bind PI3K [Homo sapiens] [Reaction:74712] Dissociation of IRS-P from insulin receptor [Homo sapiens] [Reaction:2428926] IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 [Homo sapiens] [Reaction:9607224] Active FLT3:GRB2:p-Y-GAB2 binds PIK3R1 [Homo sapiens] [BlackBoxEvent:9606622] GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated [Homo sapiens]
releaseDate	2010-03-16
reviewed	[InstanceEdit:192607] Mohammadi, M, 2007-02-06 21:44:35
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105166] R-HSA-109699.5
summation	[Summation:179084] PI3K can be activated downstream of receptor tyrosine kinase...
(hasEvent)	[Pathway:109704] PI3K Cascade [Homo sapiens]
(inferredFrom)	[Reaction:112090] AGE-1 mediated phosphorylation of PIP2 to PIP3 [Caenorhabditis elegans]
(precedingEvent)	[Reaction:109700] AKT2 binds PIP3 [Homo sapiens] [Reaction:109701] PDPK1 binds PIP3 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780013] Update Tracker - [Reaction:109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 - v64:[addLiteratureReference, modifyText] [_UpdateTracker:9780378] Update Tracker - [Reaction:109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 - v63:[add_removeOutput] [_UpdateTracker:9788016] Update Tracker - [Reaction:109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 - v44:[add_removeInput]
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