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Details on Person deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK)

Class:Id	Reaction:109671
_displayName	deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK)
_doRelease	TRUE
_timestamp	2025-12-16 18:01:42
catalystActivity	[CatalystActivity:73517] nucleoside kinase activity of DCK dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643457] nucleoside kinase activity of DCK dimer [cytosol] Deoxycytidine kinase from human leukemic spleen: preparation and characterization of the homogeneous enzyme
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:109645] D'Eustachio, P, 2004-01-19 14:08:00
crossReference	[DatabaseIdentifier:9976237] RHEA:23453 [DatabaseIdentifier:9976221] RHEA:19202
input	[DefinedSet:500201] dA, dG [cytosol] [SimpleEntity:113592] ATP [cytosol]
internalReviewed	[InstanceEdit:9977060] D'Eustachio, Peter, 2025-12-16
literatureReference	[LiteratureReference:109646] Deoxycytidine kinase from human leukemic spleen: preparation and characterization of the homogeneous enzyme [LiteratureReference:109655] Human T-lymphoblast deoxycytidine kinase: purification and properties [LiteratureReference:109657] The intracellular localization of deoxycytidine kinase
modified	[InstanceEdit:109918] D'Eustachio, P, 2004-01-22 15:13:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:500200] D'Eustachio, P, 2010-02-01 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8956390] D'Eustachio, Peter, 2017-01-22 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9976236] D'Eustachio, Peter, 2025-12-09 [InstanceEdit:9977061] D'Eustachio, Peter, 2025-12-16 [InstanceEdit:9977063] D'Eustachio, Peter, 2025-12-16
name	deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) 2'-deoxyadenosine + ATP => dAMP + ADP + H(+) 2'-deoxyguanosine + ATP => dGMP + ADP + H(+)
output	[DefinedSet:500199] dAMP, dGMP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:70106] H+ [cytosol]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2004-07-06
reviewed	[InstanceEdit:9977064] D'Eustachio, Peter, 2025-12-16
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359157] R-HSA-109671.6
structureModified	[InstanceEdit:9976236] D'Eustachio, Peter, 2025-12-09
summation	[Summation:178258] Cytosolic deoxycytidine kinase (DCK) catalyzes the reactions...
(hasEvent)	[Pathway:74217] Purine salvage [Homo sapiens]
(replacementInstances)	[_Deleted:500203] Deletion of instance: 109686
(updatedInstance)	[_UpdateTracker:9791099] Update Tracker - [Reaction:109671] deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) - v32:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText] [_UpdateTracker:9984590] Update Tracker - [Reaction:109671] deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK) - v96:[removeOutput]
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