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Details on Person (2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)

Class:IdReaction:109624
_displayName(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)
_doReleaseTRUE
_timestamp2025-12-16 18:01:14
catalystActivity[CatalystActivity:76547] adenosine kinase activity of ADK [cytosol]
catalystActivityReference[CatalystActivityReference:9643275] adenosine kinase activity of ADK [cytosol] Purification and properties of human placental adenosine kinase
compartment[Compartment:70101] cytosol
created[InstanceEdit:109609] D'Eustachio, P, 2004-01-16 17:45:00
crossReference[DatabaseIdentifier:9976253] RHEA:20825
input[DefinedSet:500173] Ade-Rib, dA [cytosol]
[SimpleEntity:113592] ATP [cytosol]
internalReviewed[InstanceEdit:9977060] D'Eustachio, Peter, 2025-12-16
literatureReference[LiteratureReference:109620] Regulation of deoxyadenosine and nucleoside analog phosphorylation by human placental adenosine kinase
[LiteratureReference:109610] Effects of mutational loss of adenosine kinase and deoxycytidine kinase on deoxyATP accumulation and deoxyadenosine toxicity in cultured CEM human T-lymphoblastoid cells
[LiteratureReference:76543] Structure of human adenosine kinase at 1.5 A resolution
[LiteratureReference:109587] Purification and properties of human placental adenosine kinase
modified[InstanceEdit:109918] D'Eustachio, P, 2004-01-22 15:13:00
[InstanceEdit:110754] D'Eustachio, P, 2004-02-06 14:15:00
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:500179] D'Eustachio, P, 2010-02-01
[InstanceEdit:504063] D'Eustachio, P, 2010-02-05
[InstanceEdit:504071] D'Eustachio, P, 2010-02-07
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:8956390] D'Eustachio, Peter, 2017-01-22
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9976255] D'Eustachio, Peter, 2025-12-09
[InstanceEdit:9977061] D'Eustachio, Peter, 2025-12-16
[InstanceEdit:9977063] D'Eustachio, Peter, 2025-12-16
name(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)
adenosine + ATP => AMP + ADP + H(+)
output[DefinedSet:500088] (d)AMP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:70106] H+ [cytosol]
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2004-07-06
reviewed[InstanceEdit:9977064] D'Eustachio, Peter, 2025-12-16
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360480] R-HSA-109624.6
structureModified[InstanceEdit:9976255] D'Eustachio, Peter, 2025-12-09
summation[Summation:178257] Cytosolic adenosine kinase (ADK) catalyzes the reactions of ...
(hasEvent)[Pathway:74217] Purine salvage [Homo sapiens]
(precedingEvent)[Reaction:74220] (d)AMP + ATP <=> (d)ADP + ADP (AK1) [Homo sapiens]
(replacementInstances)[_Deleted:500182] Deletion of instance: 76548
(updatedInstance)[_UpdateTracker:9776628] Update Tracker - [Reaction:109624] (2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) - v75:[modifyText]
[_UpdateTracker:9790877] Update Tracker - [Reaction:109624] (2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
[_UpdateTracker:9984740] Update Tracker - [Reaction:109624] (2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK) - v96:[removeOutput]
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