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Details on Person TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C]

Class:Id	Reaction:109480
_displayName	TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C]
_doRelease	TRUE
_timestamp	2025-12-11 22:36:11
catalystActivity	[CatalystActivity:109469] 5'-nucleotidase activity of NT5C dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643849] 5'-nucleotidase activity of NT5C dimer [cytosol] Cytoplasmic 5'(3')-nucleotidase from human placenta
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:109462] D'Eustachio, P, 2004-01-09 08:30:00
crossReference	[DatabaseIdentifier:9976510] RHEA:11081 [DatabaseIdentifier:9976502] RHEA:37356 [DatabaseIdentifier:9976504] RHEA:27891 [DatabaseIdentifier:9976527] RHEA:29360 [DatabaseIdentifier:9976500] RHEA:29356
input	[DefinedSet:500414] TMP, U2MP, U3MP, UMP, dU3MP, dUMP [cytosol] [SimpleEntity:29356] H2O [cytosol]
literatureReference	[LiteratureReference:109348] Cytosolic high Km 5'-nucleotidase and 5'(3')-deoxyribonucleotidase in substrate cycles involved in nucleotide metabolism [LiteratureReference:109465] Cytoplasmic 5'(3')-nucleotidase from human placenta [LiteratureReference:109473] Mammalian 5'(3')-deoxyribonucleotidase, cDNA cloning, and overexpression of the enzyme in Escherichia coli and mammalian cells
modified	[InstanceEdit:109559] D'Eustachio, P, 2004-01-14 14:55:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:500416] D'Eustachio, P, 2010-02-03 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9976516] D'Eustachio, Peter, 2025-12-11
name	TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] dTMP + H2O => thymidine + phosphate uridine 2'-phosphate + H2O => uridine + phosphate 3'-UMP + H2O => uridine + phosphate UMP + H2O => uridine + phosphate dUMP + H2O => 2'-deoxyuridine + phosphate
output	[DefinedSet:500415] Thy-Rib, (d)U [cytosol] [SimpleEntity:29372] Pi [cytosol]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359716] R-HSA-109480.5
summation	[Summation:178313] Cytosolic 5'3'-nucleotidase (NT5C) catalyzes the hydrolysis ...
(hasEvent)	[Pathway:73621] Pyrimidine catabolism [Homo sapiens]
(replacementInstances)	[_Deleted:500418] Deletion of instance: 109471 [_Deleted:500419] Deletion of instances: 109487, 109486, 109485, 109484, 109481
(updatedInstance)	[_UpdateTracker:9791050] Update Tracker - [Reaction:109480] TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
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No pathways have been reviewed or authored by TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C] (109480)