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Details on Person (d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C)

Class:Id	Reaction:109470
_displayName	(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C)
_doRelease	TRUE
_timestamp	2025-12-10 22:49:42
catalystActivity	[CatalystActivity:109469] 5'-nucleotidase activity of NT5C dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643849] 5'-nucleotidase activity of NT5C dimer [cytosol] Cytoplasmic 5'(3')-nucleotidase from human placenta
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:109462] D'Eustachio, P, 2004-01-09 08:30:00
crossReference	[DatabaseIdentifier:9976355] RHEA:27715 [DatabaseIdentifier:9976336] RHEA:29380 [DatabaseIdentifier:9976361] RHEA:27719 [DatabaseIdentifier:9976350] RHEA:29384
input	[DefinedSet:500120] (d)GMP, (d)IMP [cytosol] [SimpleEntity:29356] H2O [cytosol]
literatureReference	[LiteratureReference:109465] Cytoplasmic 5'(3')-nucleotidase from human placenta [LiteratureReference:109348] Cytosolic high Km 5'-nucleotidase and 5'(3')-deoxyribonucleotidase in substrate cycles involved in nucleotide metabolism [LiteratureReference:109473] Mammalian 5'(3')-deoxyribonucleotidase, cDNA cloning, and overexpression of the enzyme in Escherichia coli and mammalian cells
modified	[InstanceEdit:109559] D'Eustachio, P, 2004-01-14 14:55:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:500129] D'Eustachio, P, 2010-01-31 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8956390] D'Eustachio, Peter, 2017-01-22 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9976335] D'Eustachio, Peter, 2025-12-10
name	(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) GMP + H2O => guanosine + phosphate dGMP + H2O => 2'-deoxyguanosine + phosphate IMP + H2O => inosine + phosphate dIMP + H2O => 2'-deoxyinosine + phosphate
output	[DefinedSet:500118] Gu-Rib, dG, Ino, dI [cytosol] [SimpleEntity:29372] Pi [cytosol]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360734] R-HSA-109470.6
summation	[Summation:178302] Cytosolic 5'3'-nucleotidase (NT5C) catalyzes the hydrolysis ...
(hasEvent)	[Pathway:74259] Purine catabolism [Homo sapiens]
(replacementInstances)	[_Deleted:500130] Deletion of instances: 109483, 109482, 109479 [_Deleted:500418] Deletion of instance: 109471
(updatedInstance)	[_UpdateTracker:9790932] Update Tracker - [Reaction:109470] (d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
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No pathways have been reviewed or authored by (d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C) (109470)