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Details on Person (d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)

Class:Id	Reaction:109449
_displayName	(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)
_doRelease	TRUE
_timestamp	2025-12-11 22:35:47
catalystActivity	[CatalystActivity:109441] 5'-nucleotidase activity of NT5C3 holoenzyme [cytosol]
catalystActivityReference	[CatalystActivityReference:9643361] 5'-nucleotidase activity of NT5C3 holoenzyme [cytosol] Pyrimidine nucleotidases from human erythrocyte possess phosphotransferase activities specific for pyrimidine nucleotides
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:109422] D'Eustachio, P, 2004-01-07 17:02:00
crossReference	[DatabaseIdentifier:9976517] RHEA:29368 [DatabaseIdentifier:9976525] RHEA:29364 [DatabaseIdentifier:9976510] RHEA:11081 [DatabaseIdentifier:9976527] RHEA:29360 [DatabaseIdentifier:9976500] RHEA:29356
input	[DefinedSet:500347] (d)CMP, TMP, (d)UMP [cytosol] [SimpleEntity:29356] H2O [cytosol]
literatureReference	[LiteratureReference:109440] Human erythrocyte pyrimidine 5'-nucleotidase, PN-I [LiteratureReference:109434] Pyrimidine nucleotidases from human erythrocyte possess phosphotransferase activities specific for pyrimidine nucleotides [LiteratureReference:109444] Genetic basis of hemolytic anemia caused by pyrimidine 5' nucleotidase deficiency [LiteratureReference:109428] Pyrimidine 5' nucleotidase deficiency
modified	[InstanceEdit:109559] D'Eustachio, P, 2004-01-14 14:55:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:500408] D'Eustachio, P, 2010-02-03 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8956390] D'Eustachio, Peter, 2017-01-22 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9976516] D'Eustachio, Peter, 2025-12-11
name	(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) CMP + H2O => cytidine + phosphate dCMP + H2O => 2'-deoxycytidine + phosphate dTMP + H2O => thymidine + phosphate UMP + H2O => uridine + phosphate dUMP + H2O => 2'-deoxyuridine + phosphate
output	[DefinedSet:500346] (d)C, T, (d)U [cytosol] [SimpleEntity:29372] Pi [cytosol]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358804] R-HSA-109449.6
summation	[Summation:178287] Cytosolic 5'-nucleotidase 3 (NT5C3) catalyzes the hydrolysis...
(hasEvent)	[Pathway:73621] Pyrimidine catabolism [Homo sapiens]
(replacementInstances)	[_Deleted:500409] Deletion of instance: 109442 [_Deleted:500410] Deletion of instances: 109451, 109450, 109448, 109447
(updatedInstance)	[_UpdateTracker:9791241] Update Tracker - [Reaction:109449] (d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
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No pathways have been reviewed or authored by (d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3) (109449)