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Details on Person Activated mammalian MEK1/2 is a serine/threonine kinase, wh...

Class:IdSummation:1094364
_displayNameActivated mammalian MEK1/2 is a serine/threonine kinase, wh...
_timestamp2011-02-21 19:25:50
created[InstanceEdit:1094361] Shamovsky, V, 2010-11-29
literatureReference[LiteratureReference:1094359] Extracellular signal-regulated kinase (ERK) activation in chicken heterophils stimulated with phorbol 12-myristate 13-acetate (PMA), formyl-methionylleucyl-phenylalanine (fMLP) and lipopolysaccharide (LPS)
[LiteratureReference:517851] Flagellin and lipopolysaccharide stimulate the MEK-ERK signaling pathway in chicken heterophils through differential activation of the small GTPases, Ras and Rap1
[LiteratureReference:571255] Flagellin and lipopolysaccharide up-regulation of IL-6 and CXCLi2 gene expression in chicken heterophils is mediated by ERK1/2-dependent activation of AP-1 and NF-kappaB signaling pathways
modified[InstanceEdit:1220566] Shamovsky, V, 2011-02-21
textActivated mammalian MEK1/2 is a serine/threonine kinase, which phosphorylates and activates ERK1/2. ERK1/2 is then translocates to the nucleus and activates transcription factors.

Chicken MEK2 showes 93% amino acid sequence identity to human MEK2. Multiple sequence alignment of human, mouse and chicken MEK2 by ClustalW allows to predict that the following chicken residues are involved in chicken MEK2 activation: Ser220 and Ser224 that are corresponding to human residues Ser222 and Ser226.

(summation)[Reaction:451482] activated MEK2 binds ERK2 [Gallus gallus]
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