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Details on Person Lipopolysaccharide and flagellin were shown to stimulate ERK...

Class:IdSummation:1094362
_displayNameLipopolysaccharide and flagellin were shown to stimulate ERK...
_timestamp2019-02-01 19:29:27
created[InstanceEdit:1094361] Shamovsky, V, 2010-11-29
literatureReference[LiteratureReference:517851] Flagellin and lipopolysaccharide stimulate the MEK-ERK signaling pathway in chicken heterophils through differential activation of the small GTPases, Ras and Rap1
[LiteratureReference:571255] Flagellin and lipopolysaccharide up-regulation of IL-6 and CXCLi2 gene expression in chicken heterophils is mediated by ERK1/2-dependent activation of AP-1 and NF-kappaB signaling pathways
[LiteratureReference:1094359] Extracellular signal-regulated kinase (ERK) activation in chicken heterophils stimulated with phorbol 12-myristate 13-acetate (PMA), formyl-methionylleucyl-phenylalanine (fMLP) and lipopolysaccharide (LPS)
[LiteratureReference:1094360] Advances in avian immunology--prospects for disease control: a review
modified[InstanceEdit:9635368] Shamovsky, Veronica, 2019-02-01
[InstanceEdit:9635372] Shamovsky, Veronica, 2019-02-01
textLipopolysaccharide and flagellin were shown to stimulate ERK activation in chicken heterophils.

Bioinformatic analysis reveals no evidence of ERK1 in the chicken genome, although chicken orthologs to other mediators of MEK-ERK signaling (MEK1, MEK2, ERK2 etc.) were identified. In this Reactome model we show ERK2 activation and assume that chicken MEK-ERK mediators behave like their human counterparts.

(summation)[Pathway:451478] ERK activation [Gallus gallus]
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