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Details on Person (2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A]

Class:Id	Reaction:109387
_displayName	(2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A]
_doRelease	TRUE
_timestamp	2025-12-10 22:49:41
catalystActivity	[CatalystActivity:109365] 5'-nucleotidase activity of NT5C1A tetramer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643499] 5'-nucleotidase activity of NT5C1A tetramer [cytosol] Human cytosolic 5'-nucleotidase I. Characterization and role in nucleoside analog resistance
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:109356] D'Eustachio, P, 2004-01-06 13:35:00
crossReference	[DatabaseIdentifier:9976334] RHEA:29376 [DatabaseIdentifier:9976341] RHEA:29372 [DatabaseIdentifier:9976355] RHEA:27715 [DatabaseIdentifier:9976336] RHEA:29380 [DatabaseIdentifier:9976361] RHEA:27719 [DatabaseIdentifier:9976350] RHEA:29384
input	[DefinedSet:500125] (d)AMP, (d)GMP, (d)IMP [cytosol] [SimpleEntity:29356] H2O [cytosol]
literatureReference	[LiteratureReference:109306] Mammalian 5'-nucleotidases [LiteratureReference:109358] Human cytosolic 5'-nucleotidase I. Characterization and role in nucleoside analog resistance [LiteratureReference:109372] The mechanism of adenosine formation in cells. Cloning of cytosolic 5'-nucleotidase-I [LiteratureReference:109364] Partial purification and properties of an AMP-specific soluble 5'-nucleotidase from pigeon heart
modified	[InstanceEdit:109559] D'Eustachio, P, 2004-01-14 14:55:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:500123] D'Eustachio, P, 2010-01-31 [InstanceEdit:500128] D'Eustachio, P, 2010-01-31 [InstanceEdit:500345] D'Eustachio, P, 2010-02-03 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8956390] D'Eustachio, Peter, 2017-01-22 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9976335] D'Eustachio, Peter, 2025-12-10
name	(2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A] AMP + H2O => adenosine + phosphate dAMP + H2O => 2'-deoxyadenosine + phosphate GMP + H2O => guanosine + phosphate dGMP + H2O => 2'-deoxyguanosine + phosphate IMP + H2O => inosine + phosphate dIMP + H2O => 2'-deoxyinosine + phosphate
output	[DefinedSet:500124] (d)A, (d)G, (d)I [cytosol] [SimpleEntity:29372] Pi [cytosol]
regulatedBy	[PositiveRegulation:109388] Positive regulation by 'ADP [cytosol]'
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361513] R-HSA-109387.7
summation	[Summation:178270] Cytosolic 5'-nucleotidase IA catalyzes the hydrolysis of pur...
(hasEvent)	[Pathway:74259] Purine catabolism [Homo sapiens]
(replacementInstances)	[_Deleted:500126] Deletion of instances: 109400, 109398, 109393, 109391, 109389 [_Deleted:500350] Deletion of instance: 109368
(updatedInstance)	[_UpdateTracker:9791070] Update Tracker - [Reaction:109387] (d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A) - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
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