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Details on Person (d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)

Class:Id	Reaction:109380
_displayName	(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)
_doRelease	TRUE
_timestamp	2025-12-11 22:35:46
catalystActivity	[CatalystActivity:109365] 5'-nucleotidase activity of NT5C1A tetramer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643499] 5'-nucleotidase activity of NT5C1A tetramer [cytosol] Human cytosolic 5'-nucleotidase I. Characterization and role in nucleoside analog resistance
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:109356] D'Eustachio, P, 2004-01-06 13:35:00
crossReference	[DatabaseIdentifier:9976517] RHEA:29368 [DatabaseIdentifier:9976525] RHEA:29364 [DatabaseIdentifier:9976510] RHEA:11081 [DatabaseIdentifier:9976527] RHEA:29360 [DatabaseIdentifier:9976500] RHEA:29356
input	[DefinedSet:500347] (d)CMP, TMP, (d)UMP [cytosol] [SimpleEntity:29356] H2O [cytosol]
literatureReference	[LiteratureReference:109306] Mammalian 5'-nucleotidases [LiteratureReference:109358] Human cytosolic 5'-nucleotidase I. Characterization and role in nucleoside analog resistance [LiteratureReference:109372] The mechanism of adenosine formation in cells. Cloning of cytosolic 5'-nucleotidase-I [LiteratureReference:109364] Partial purification and properties of an AMP-specific soluble 5'-nucleotidase from pigeon heart
modified	[InstanceEdit:109559] D'Eustachio, P, 2004-01-14 14:55:00 [InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51 [InstanceEdit:500345] D'Eustachio, P, 2010-02-03 [InstanceEdit:504063] D'Eustachio, P, 2010-02-05 [InstanceEdit:504071] D'Eustachio, P, 2010-02-07 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8956390] D'Eustachio, Peter, 2017-01-22 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9976516] D'Eustachio, Peter, 2025-12-11
name	(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) CMP + H2O => cytidine + phosphate dCMP + H2O => 2'-deoxycytidine + phosphate dTMP + H2O => thymidine + phosphate UMP + H2O => uridine + phosphate dUMP + H2O => 2'-deoxyuridine + phosphate
output	[DefinedSet:500346] (d)C, T, (d)U [cytosol] [SimpleEntity:29372] Pi [cytosol]
regulatedBy	[PositiveRegulation:109381] Positive regulation by 'ADP [cytosol]'
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361607] R-HSA-109380.7
summation	[Summation:178286] Cytosolic 5'-nucleotidase IA (NT5C1A) catalyzes the hydrolys...
(hasEvent)	[Pathway:73621] Pyrimidine catabolism [Homo sapiens]
(replacementInstances)	[_Deleted:500349] Deletion of instances: 109403, 109396, 109384, 109367, 74396, 74395, 73609, 73602, 73562, 73553 [_Deleted:500350] Deletion of instance: 109368
(updatedInstance)	[_UpdateTracker:9790874] Update Tracker - [Reaction:109380] (d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) - v32:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
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No pathways have been reviewed or authored by (d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A) (109380)