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Details on Person UniProt:Q62520 Zic2
| Class:Id | ReferenceGeneProduct:108873 |
|---|---|
| _chainChangeLog | chain:1-530 added on Sat February 7 2015 |
| _displayName | UniProt:Q62520 Zic2 |
| _timestamp | 2023-11-03 15:54:16 |
| chain | chain:1-530 |
| checksum | BE8B476E81B1E40B |
| comment | FUNCTION Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos.SUBUNIT Interacts with RNF180 (PubMed:18363970). Interacts (via the C2H2-type domains 3, 4 and 5) with MDFIC (via the C2H2-type domains 3, 4 and 5); the interaction reduces its transcriptional activity (PubMed:15207726, PubMed:15465018). Interacts (via C2H2-type domain 3) with DHX9 (PubMed:18068128). Interacts with GLI1 and GLI2 (PubMed:11238441).INTERACTION Localizes in the cytoplasm in presence of MDFIC overexpression. Both phosphorylated and unphosphorylated forms are localized in the nucleus.TISSUE SPECIFICITY CNS. A high level expression is seen in the cerebellum.DEVELOPMENTAL STAGE Expressed in the ipsilateral retinal ganglion cells (iRGCs) of the peripheral ventrotemporal (VT) neural retina, during the outgrowth of the uncrossed retinal projection between 16.5 and 18.5 dpc (at protein level). Expression is down-regulated as RGCs extend toward chiasmatic midline at the optic chiasm.DOMAIN The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation.PTM Phosphorylated.PTM Ubiquitinated by RNF180, leading to its degradation.DISRUPTION PHENOTYPE Mice show impaired dorsal forebrain development and insufficient closure of the posterior neuropore. Mice survive with holoprosencephaly (HPE) and spina bifida.SIMILARITY Belongs to the GLI C2H2-type zinc-finger protein family. |
| description | recommendedName: Zinc finger protein ZIC 2 alternativeName: Zinc finger protein of the cerebellum 2 |
| geneName | Zic2 |
| identifier | Q62520 |
| isSequenceChanged | FALSE |
| keyword | Activator Cytoplasm Developmental protein Differentiation DNA-binding Isopeptide bond Metal-binding Neurogenesis Nucleus Phosphoprotein Reference proteome Repeat Repressor Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Zic2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | ZIC2_MOUSE |
| sequenceLength | 530 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9832927] Zic2 [nucleoplasm] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q62520 Zic2 (108873)
