Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person The complex of interleukin-6 (IL6) bound to the IL6 receptor...
| Class:Id | Summation:1067686 |
|---|---|
| _displayName | The complex of interleukin-6 (IL6) bound to the IL6 receptor... |
| _timestamp | 2025-12-01 18:26:46 |
| created | [InstanceEdit:1067679] Jupe, S, 2010-11-26 |
| literatureReference | [LiteratureReference:449998] Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130 |
| modified | [InstanceEdit:1112527] Jupe, S, 2010-12-03 [InstanceEdit:8963884] Jupe, Steve, 2017-02-13 [InstanceEdit:9975420] Orlic-Milacic, Marija, 2025-12-01 |
| text | The complex of interleukin-6 (IL6) bound to the IL6 receptor α subunit (IL6R) binds the IL-6 receptor β subunit IL6ST (gp130), which constitutively binds JAK kinases. Site II of IL6 interacts with the cytokine binding-homology region of IL6ST. Subsequently, site III of IL6 interacts with the IL6ST immunoglobulin-like activation domain. |
| (summation) | [Reaction:1067688] IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by The complex of interleukin-6 (IL6) bound to the IL6 receptor... (1067686)
