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Details on Person Assembly of hexameric IL-6 receptor

Class:Id	Reaction:1067659
_displayName	Assembly of hexameric IL-6 receptor
_doRelease	TRUE
_timestamp	2025-12-01 18:25:33
authored	[InstanceEdit:1164950] Ray, K, 2010-12-13
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1067679] Jupe, S, 2010-11-26
edited	[InstanceEdit:1112767] Jupe, S, 2010-12-10
input	[DefinedSet:1112523] IL6 receptor trimer:JAKs [plasma membrane] [Homo sapiens] [DefinedSet:1112523] IL6 receptor trimer:JAKs [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:449993] Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex
modified	[InstanceEdit:1112527] Jupe, S, 2010-12-03 [InstanceEdit:1164953] Jupe, S, 2010-12-13 [InstanceEdit:1214160] Jupe, S, 2011-02-11 [InstanceEdit:8963884] Jupe, Steve, 2017-02-13 [InstanceEdit:9020559] Duenas, Corina, 2017-09-07 [InstanceEdit:9028437] Jupe, Steve, 2017-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9975420] Orlic-Milacic, Marija, 2025-12-01
name	Assembly of hexameric IL-6 receptor
output	[Complex:1112588] IL6 receptor hexamer:JAKs [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1067688] IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) [Homo sapiens] [Reaction:1067667] IL6 binds IL6R [Homo sapiens] [Reaction:1067646] JAK1,JAK2,(TYK2) bind IL6ST [Homo sapiens] [Reaction:1067651] IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) [Homo sapiens] [Reaction:1067640] IL6 binds IL6R-2 [Homo sapiens] [Reaction:1067646] JAK1,JAK2,(TYK2) bind IL6ST [Homo sapiens]
releaseDate	2011-03-15
reviewed	[InstanceEdit:1214159] Rose-John, S, 2011-02-11 [InstanceEdit:9975417] Raptis, Leda, 2025-11-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1224983] R-HSA-1067659.5
summation	[Summation:1067649] There are three contact sites between IL-6, IL-6R and gp1...
(hasEvent)	[Pathway:1059683] Interleukin-6 signaling [Homo sapiens] [Pathway:9958825] Activation of STAT3 by cadherin engagement [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:1112514] JAK activation [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780506] Update Tracker - [Reaction:1067659] Assembly of hexameric IL-6 receptor - v62:[modifyText] [_UpdateTracker:9781650] Update Tracker - [Reaction:1067659] Assembly of hexameric IL-6 receptor - v60:[modifyText] [_UpdateTracker:9984627] Update Tracker - [Reaction:1067659] Assembly of hexameric IL-6 receptor - v96:[modifyText]
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