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Details on Person IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)

Class:Id	Reaction:1067651
_displayName	IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
_doRelease	TRUE
_timestamp	2025-12-01 18:25:58
authored	[InstanceEdit:1164950] Ray, K, 2010-12-13
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:1067679] Jupe, S, 2010-11-26
edited	[InstanceEdit:1112767] Jupe, S, 2010-12-10
input	[Complex:1067687] IL6:IL6R-2 [extracellular region] [Homo sapiens] [Complex:1067690] IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:449998] Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130 [LiteratureReference:1164954] Molecular cloning and expression of an IL-6 signal transducer, gp130
modified	[InstanceEdit:1112527] Jupe, S, 2010-12-03 [InstanceEdit:1164953] Jupe, S, 2010-12-13 [InstanceEdit:1214160] Jupe, S, 2011-02-11 [InstanceEdit:8963884] Jupe, Steve, 2017-02-13 [InstanceEdit:9020559] Duenas, Corina, 2017-09-07 [InstanceEdit:9028437] Jupe, Steve, 2017-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9975420] Orlic-Milacic, Marija, 2025-12-01
name	IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) IL6:sIL6R binds to JAKs:IL6RB (gp130)
output	[Complex:1067691] IL6:sIL6R:IL6RB:JAKs [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1067640] IL6 binds IL6R-2 [Homo sapiens] [Reaction:1067646] JAK1,JAK2,(TYK2) bind IL6ST [Homo sapiens]
regulatedBy	[NegativeRegulation:1164957] Negative regulation by 'IL6:IL6R-2:IL6ST-2 [extracellular region]'
releaseDate	2011-03-15
reviewed	[InstanceEdit:1214159] Rose-John, S, 2011-02-11 [InstanceEdit:9975417] Raptis, Leda, 2025-11-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1225071] R-HSA-1067651.6
summation	[Summation:1067684] The complex of interleukin-6 (IL6) and the soluble, short fo...
(hasEvent)	[Pathway:1059683] Interleukin-6 signaling [Homo sapiens] [Pathway:9958825] Activation of STAT3 by cadherin engagement [Homo sapiens]
(precedingEvent)	[Reaction:1067659] Assembly of hexameric IL-6 receptor [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781986] Update Tracker - [Reaction:1067651] IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) - v60:[modifyText]
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No pathways have been reviewed or authored by IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) (1067651)