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Details on Person JAK1,JAK2,(TYK2) bind IL6ST

Class:IdReaction:1067646
_displayNameJAK1,JAK2,(TYK2) bind IL6ST
_doReleaseTRUE
_timestamp2025-12-01 18:26:18
authored[InstanceEdit:1164950] Ray, K, 2010-12-13
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:1067679] Jupe, S, 2010-11-26
edited[InstanceEdit:1112767] Jupe, S, 2010-12-10
inferredFrom
input[CandidateSet:1067656] JAK1, JAK2, (TYK2) [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:448453] IL6ST [plasma membrane] [Homo sapiens]
isChimericFALSE
modified[InstanceEdit:1164953] Jupe, S, 2010-12-13
[InstanceEdit:1214160] Jupe, S, 2011-02-11
[InstanceEdit:3006340] Jupe, S, 2013-01-30
[InstanceEdit:8963884] Jupe, Steve, 2017-02-13
[InstanceEdit:9006072] Duenas, Corina, 2017-05-12
[InstanceEdit:9020559] Duenas, Corina, 2017-09-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9975420] Orlic-Milacic, Marija, 2025-12-01
nameJAK1,JAK2,(TYK2) bind IL6ST
JAKs associate with IL6ST (gp130)
output[Complex:1067690] IL6ST:JAK1, JAK2, (TYK2) [plasma membrane] [Homo sapiens]
releaseDate2011-03-15
reviewed[InstanceEdit:1214159] Rose-John, S, 2011-02-11
[InstanceEdit:9975417] Raptis, Leda, 2025-11-21
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1224913] R-HSA-1067646.6
summation[Summation:1067639] The tyrosine kinases JAK1, JAK2 and Tyk2 associate with the ...
(hasEvent)[Pathway:1059683] Interleukin-6 signaling [Homo sapiens]
[Pathway:9020956] Interleukin-27 signaling [Homo sapiens]
[Pathway:9958825] Activation of STAT3 by cadherin engagement [Homo sapiens]
(precedingEvent)[Reaction:1067651] IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2) [Homo sapiens]
[Reaction:1067688] IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) [Homo sapiens]
[Reaction:6783530] gp130:JAKs bind CNTFR [Homo sapiens]
[BlackBoxEvent:6809140] IL35 binds IL-12RB2:IL6ST receptor [Homo sapiens]
[BlackBoxEvent:8983518] IL35 binds IL6ST:IL6ST receptor [Homo sapiens]
(updatedInstance)[_UpdateTracker:9781874] Update Tracker - [Reaction:1067646] JAK1,JAK2,(TYK2) bind IL6ST - v60:[modifyText]
[_UpdateTracker:9788035] Update Tracker - [Reaction:1067646] JAK1,JAK2,(TYK2) bind IL6ST - v44:[add_removeInput]
[_UpdateTracker:9984577] Update Tracker - [Reaction:1067646] JAK1,JAK2,(TYK2) bind IL6ST - v96:[modifyText]
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