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Details on Person UniProt:Q8R5M2 Wnt9a
| Class:Id | ReferenceGeneProduct:104905 |
|---|---|
| _chainChangeLog | signal peptide:1-29 added on Fri February 6 2015;chain:30-365 added on Fri February 6 2015 |
| _displayName | UniProt:Q8R5M2 Wnt9a |
| _timestamp | 2023-11-03 16:49:17 |
| chain | signal peptide:1-29 chain:30-365 |
| checksum | C6EBBE1897D2FA8A |
| comment | FUNCTION Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development (PubMed:16818445). Plays a redundant role in maintaining joint integrity (PubMed:16818445).SUBUNIT Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids.SUBCELLULAR LOCATION Expressed in adult brain, lung, skeletal muscle, heart, and 17-day embryo.PTM Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.DISRUPTION PHENOTYPE Mutant mice die during the first 12 hours after birth. Heart, lung, liver, intestinal tract, kidney and brain appear grossly normal, but the mice display skeletal abnormalities, with slightly shortened long bones in their limbs. The region of bone mineralization is reduced in scapula, humerus, ileum and femur. Besides, hyoid bone and atlas are hypoplastic. In the scull, the supraoccipital bone shows reduced mineralization, with increased distance between the frontal bones. The basioccipital bone displays an abnormal shape and is smaller than in wild-type. Ectopic cartilage nodules are detected within the skull midline sutures. Ectopic cartilaginous material is detected in the interfrontal and sagittal suture regions between the frontal and parietal bones. In neonate forelimbs, the synovial fold contains cells with a chondrocyte-like appearance. Mutant mice display also partial joint fusions between the navicular and intermediate cuneiform tarsal elements in the foot, and between wrist carpal elements.SIMILARITY Belongs to the Wnt family. |
| description | recommendedName: Protein Wnt-9a alternativeName: Protein Wnt-14 |
| geneName | Wnt9a Wnt14 |
| identifier | Q8R5M2 |
| isSequenceChanged | FALSE |
| keyword | Developmental protein Disulfide bond Extracellular matrix Glycoprotein Lipoprotein Reference proteome Secreted Signal Wnt signaling pathway |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:5691543] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9607352] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Wnt9a |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | WNT9A_MOUSE |
| sequenceLength | 365 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:3769339] N4GlycoAsn-PalmS Wnt9a [extracellular region] [Mus musculus] |
| (referenceSequence) | [ModifiedResidue:3769341] N4-glycosyl-L-asparagine at 103 [ModifiedResidue:3769349] O-palmitoleyl-L-serine at 221 |
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No pathways have been reviewed or authored by UniProt:Q8R5M2 Wnt9a (104905)
