Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P48614 Wnt10b
| Class:Id | ReferenceGeneProduct:104895 |
|---|---|
| _chainChangeLog | signal peptide:1-28 added on Fri February 6 2015;chain:29-389 added on Fri February 6 2015 |
| _displayName | UniProt:P48614 Wnt10b |
| _timestamp | 2023-11-03 15:13:41 |
| chain | signal peptide:1-28 chain:29-389 |
| checksum | F990AB33B7C84633 |
| comment | FUNCTION Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin.SUBUNIT Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity. The complex with AFM may represent the physiological form in body fluids.SUBCELLULAR LOCATION Expressed in embryos and in the mammary gland of non-pregnant mice.PTM Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.SIMILARITY Belongs to the Wnt family. |
| description | recommendedName: Protein Wnt-10b alternativeName: Protein Wnt-12 |
| geneName | Wnt10b Wnt-10b Wnt10 Wnt12 |
| identifier | P48614 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Developmental protein Disulfide bond Extracellular matrix Glycoprotein Lipoprotein Phosphoprotein Reference proteome Secreted Signal Wnt signaling pathway |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:5691543] Weiser, JD [InstanceEdit:8964659] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9607352] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Wnt10b |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | WN10B_MOUSE P70702 |
| sequenceLength | 389 |
| species | [Species:48892] Mus musculus |
| (isoformParent) | [ReferenceIsoform:155793] UniProt:P48614-2 Wnt10b [Mus musculus] [ReferenceIsoform:404147] UniProt:P48614-1 Wnt10b [Mus musculus] |
| (referenceEntity) | [EntityWithAccessionedSequence:976240] Protein Wnt-10b [extracellular region] [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P48614 Wnt10b (104895)
