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Details on Person UniProt:Q16572 SLC18A3
| Class:Id | ReferenceGeneProduct:104663 |
|---|---|
| _chainChangeLog | chain:1-532 added on Sat February 7 2015 |
| _displayName | UniProt:Q16572 SLC18A3 |
| _timestamp | 2025-02-21 18:43:19 |
| chain | chain:1-532 |
| checksum | 445CDF48F08ED31D |
| comment | FUNCTION Electrogenic antiporter that exchanges one cholinergic neurotransmitter, acetylcholine or choline, with two intravesicular protons across the membrane of synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to store neurotransmitters inside the vesicles prior to their release via exocytosis (By similarity) (PubMed:20225888, PubMed:8910293). Determines cholinergic vesicular quantal size at presynaptic nerve terminals in developing neuro-muscular junctions with an impact on motor neuron differentiation and innervation pattern (By similarity). Part of forebrain cholinergic system, regulates hippocampal synapse transmissions that underlie spatial memory formation (By similarity). Can transport serotonin.CATALYTIC ACTIVITY acetylcholine(out) + 2 H(+)(in) = acetylcholine(in) + 2 H(+)(out)CATALYTIC ACTIVITY choline(in) + 2 H(+)(out) = choline(out) + 2 H(+)(in)CATALYTIC ACTIVITY serotonin(in) + 2 H(+)(out) = serotonin(out) + 2 H(+)(in)ACTIVITY REGULATION Potently inhibited by L-vesamicol, reserpine and tetrabenazine.BIOPHYSICOCHEMICAL PROPERTIES Optimum pH is 7.SUBUNIT Interacts with SEC14L1.INTERACTION Peripheral and central cholinergic nervous systems.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the major facilitator superfamily. Vesicular transporter family. |
| description | recommendedName: Vesicular acetylcholine transporter shortName: VAChT alternativeName: Solute carrier family 18 member 3 |
| geneName | SLC18A3 VACHT |
| identifier | Q16572 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Congenital myasthenic syndrome Cytoplasmic vesicle Disease variant Glycoprotein Membrane Neurotransmitter transport Proteomics identification Reference proteome Synapse Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | SLC18A3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995779] ENSEMBL:ENSG00000187714 SLC18A3 [Homo sapiens] |
| secondaryIdentifier | VACHT_HUMAN B2R7S1 |
| sequenceLength | 532 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:264619] SLC18A3 [clathrin-sculpted acetylcholine transport vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:372513] SLC18A3 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8869109] SLC18A3 [clathrin-coated endocytic vesicle membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q16572 SLC18A3 (104663)
