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Details on Person UniProt:Q9HAW7 UGT1A7
| Class:Id | ReferenceGeneProduct:104360 |
|---|---|
| _chainChangeLog | signal peptide:1-25 added on Sat February 7 2015;chain:26-530 added on Sat February 7 2015 |
| _displayName | UniProt:Q9HAW7 UGT1A7 |
| _timestamp | 2025-02-21 19:55:28 |
| chain | signal peptide:1-25 chain:26-530 |
| checksum | 7D759A382AE871D3 |
| comment | FUNCTION UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:15470161, PubMed:18004212, PubMed:18052087, PubMed:18674515, PubMed:18719240, PubMed:20610558, PubMed:23360619, PubMed:21422672, PubMed:38211441). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormone epiestradiol (PubMed:18719240). Involved in the glucuronidation of F2-isoprostane (5-epi-5-F2t-IsoP) (PubMed:38211441). Involved in the glucuronidation of the phytochemical ferulic acid at the carboxylic acid group (PubMed:21422672). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (PubMed:12181437, PubMed:18004212, PubMed:20610558, PubMed:23360619). Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161).FUNCTION Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.CATALYTIC ACTIVITY glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)CATALYTIC ACTIVITY 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha-estradiol 3-O-(beta-D-glucuronate) + UDP + H(+)CATALYTIC ACTIVITY prunetin + UDP-alpha-D-glucuronate = prunetin-5-O-beta-D-glucuronide + UDPCATALYTIC ACTIVITY 5-epi-5-F2t-IsoP + UDP-alpha-D-glucuronate = 5-epi-5-F2t-IsoP-glucuronide + UDP + H(+)CATALYTIC ACTIVITY (E)-ferulate + UDP-alpha-D-glucuronate = (E)-ferulic acid beta-D-glucuronate ester + UDPCATALYTIC ACTIVITY candesartan + UDP-alpha-D-glucuronate = candesartan O-beta-D-glucuronoside + UDPCATALYTIC ACTIVITY SN-38 + UDP-alpha-D-glucuronate = SN-38 O-beta-D-glucuronide + UDP + H(+)CATALYTIC ACTIVITY mycophenolate + UDP-alpha-D-glucuronate = mycophenolate 7-O-beta-D-glucuronide + UDP + H(+)BIOPHYSICOCHEMICAL PROPERTIES Some kinetic parameters were assessed using commercial enzymes, which may represent a mix of both active and inactive protein forms, and therefore modify the kinetic values.SUBUNIT Homodimer (PubMed:17179145). Homooligomer (Probable). Interacts with UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers (PubMed:17179145). Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A8, UGT1A9 and UGT1A10 (PubMed:20610558).SUBCELLULAR LOCATION Liver and gastric tissue (PubMed:9271343). Isoform 1 and isoform 2 are expressed in esophagus. Neither isoform is expressed in liver, kidney, colon and small intestine (PubMed:18004212).POLYMORPHISM There are four common allelic UGT1A7 variants which exhibit significant differences in catalytic activity towards 3-, 7-, and 9-hydroxy-benzo(a)pyrene. UGT1A7*3 exhibits a 5.8-fold lower relative Vmax compared to UGT1A7*1, whereas UGT1A7*2 and UGT1A7*4 have a 2.6- and 2.8-fold lower relative Vmax than UGT1A7*1, respectively, suggesting that these mutations confer slow glucuronidation phenotype.MISCELLANEOUS UGT1A7 isoform is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.SIMILARITY Belongs to the UDP-glycosyltransferase family. |
| description | recommendedName: fullName evidence="19"UDP-glucuronosyltransferase 1A7 shortName evidence="20"UGT1A7 ecNumber evidence="4 7 8 9 10 12 14"2.4.1.17 alternativeName: UDP-glucuronosyltransferase 1-7 shortName: UDPGT 1-7 shortName: UGT1*7 shortName: UGT1-07 shortName: UGT1.7 alternativeName: UDP-glucuronosyltransferase 1-G shortName: UGT-1G shortName: UGT1G |
| geneName | UGT1A7 GNT1 UGT1 |
| identifier | Q9HAW7 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Endoplasmic reticulum Glycoprotein Glycosyltransferase Lipid metabolism Membrane Proteomics identification Reference proteome Signal Transferase Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | UGT1A7 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991644] ENSEMBL:ENSG00000244122 UGT1A7 [Homo sapiens] |
| secondaryIdentifier | UD17_HUMAN B8K293 O00473 |
| sequenceLength | 530 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:414376] UniProt:Q9HAW7-1 UGT1A7 [Homo sapiens] [ReferenceIsoform:8974539] UniProt:Q9HAW7-2 UGT1A7 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:174927] UGT1A7 [endoplasmic reticulum membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9HAW7 UGT1A7 (104360)
