Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:O43818 RRP9
| Class:Id | ReferenceGeneProduct:104151 |
|---|---|
| _chainChangeLog | chain:1-475 added on Sat February 7 2015 |
| _displayName | UniProt:O43818 RRP9 |
| _timestamp | 2024-11-03 19:39:29 |
| chain | chain:1-475 |
| checksum | 3CD19F66EA75B627 |
| comment | FUNCTION Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA (pre-rRNA) (PubMed:26867678). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797).SUBUNIT Interacts specifically with the U3 small nucleolar RNA (U3 snoRNA) (PubMed:10982864, PubMed:12381732). Binds a sub-fragment of the U3 snoRNA surrounding the B/C motif (3UBC) (PubMed:10982864, PubMed:12381732). This association with the U3BC RNA is dependent on the binding of a protein called 15.5K to the box B/C motif (PubMed:10982864, PubMed:12381732). The association of the protein with the U3BC RNA was found to be also dependent on a conserved RNA structure that flanks the box B/C motif (PubMed:10982864, PubMed:12381732). Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3 (PubMed:34516797).INTERACTION The WD domains are required for nucleolar localization and U3 small nucleolar RNAs binding.PTM Acetylation at Lys-12 and Lys-25 by KAT2B/PCAF under stress impairs pre-rRNA processing (PubMed:26867678). Deacetylation by SIRT7 enhances RRP9-binding to U3 snoRNA, which is a prerequisite for pre-rRNA processing (PubMed:26867678).SIMILARITY Belongs to the WD repeat RRP9 family. |
| description | recommendedName: U3 small nucleolar RNA-interacting protein 2 alternativeName: RRP9 homolog alternativeName: fullName evidence="10"U3 small nucleolar ribonucleoprotein-associated 55 kDa protein shortName evidence="10"U3 snoRNP-associated 55 kDa protein shortName evidence="10"U3-55K |
| geneName | RRP9 RNU3IP2 U355K |
| identifier | O43818 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Direct protein sequencing Isopeptide bond Methylation Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Ribonucleoprotein RNA-binding rRNA processing Ubl conjugation WD repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | RRP9 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003902] ENSEMBL:ENSG00000114767 RRP9 [Homo sapiens] |
| secondaryIdentifier | U3IP2_HUMAN B2R996 Q8IZ30 |
| sequenceLength | 475 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:6790682] RRP9 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O43818 RRP9 (104151)
