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Details on Person UniProt:P59910 DNAJB13

Class:Id	ReferenceGeneProduct:103953
_chainChangeLog	chain:1-316 added on Fri February 6 2015
_displayName	UniProt:P59910 DNAJB13
_timestamp	2026-02-20 23:04:39
chain	chain:1-316
checksum	8251CB720724B7E5
comment	FUNCTION Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia.SUBUNIT Homodimer (PubMed:27486783). Component of the axonemal radial spoke complex 1 (RS1), at least composed of spoke head proteins RSPH1, RSPH3, RSPH9 and the cilia-specific component RSPH4A or sperm-specific component RSPH6A, spoke stalk proteins RSPH14, DNAJB13, DYDC1, ROPN1L and NME5, and the anchor protein IQUB (By similarity). Interacts with SUN5 (By similarity). Interacts with IQUB (By similarity). Interacts with DNAH12 (By similarity).INTERACTION Localizes both to epithelial motile cilium and the sperm flagellum (PubMed:27486783). In spermatids, rapidly enriched in the coupling apparatus with the elongation of the spermatid. Tightly attached to the implantation fossa during the maturation of the spermatid. In mature spermatzoa evenly distributed along the flagellum (By similarity).ALTERNATIVE PRODUCTS Specifically expressed in testis and trachea.DISEASE The disease is caused by variants affecting the gene represented in this entry.
description	recommendedName: DnaJ homolog subfamily B member 13 alternativeName: Testis and spermatogenesis cell-related protein 6 alternativeName: Testis spermatocyte apoptosis-related gene 6 protein alternativeName: Testis spermatogenesis apoptosis-related gene 3 protein alternativeName: Testis spermatogenesis apoptosis-related gene 6 protein
geneName	DNAJB13 TSARG3 TSARG6
identifier	P59910
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Cell projection Chaperone Ciliopathy Cilium Cilium biogenesis/degradation Disease variant Flagellum Primary ciliary dyskinesia Proteomics identification Reference proteome
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
name	DNAJB13
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9002919] ENSEMBL:ENSG00000187726 DNAJB13 [Homo sapiens]
secondaryIdentifier	DJB13_HUMAN B3LEP4 Q8IZW5
sequenceLength	316
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:155318] UniProt:P59910-2 DNAJB13 [Homo sapiens] [ReferenceIsoform:404568] UniProt:P59910-1 DNAJB13 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:9966747] DNAJB13 [cilium] [Homo sapiens] [EntityWithAccessionedSequence:9969357] DNAJB13 [cytosol] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:P59910 DNAJB13 (103953)