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Details on Person UniProt:Q9R0X0 Med20
| Class:Id | ReferenceGeneProduct:103792 |
|---|---|
| _chainChangeLog | chain:1-212 added on Sat February 7 2015 |
| _displayName | UniProt:Q9R0X0 Med20 |
| _timestamp | 2023-11-03 15:09:26 |
| chain | chain:1-212 |
| checksum | 88E116D0A9764438 |
| comment | FUNCTION Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).SUBUNIT Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity). Interacts with PPARG.INTERACTION Belongs to the Mediator complex subunit 20 family. |
| description | recommendedName: Mediator of RNA polymerase II transcription subunit 20 alternativeName: Mediator complex subunit 20 alternativeName: TRF-proximal protein homolog |
| geneName | Med20 Trfp |
| identifier | Q9R0X0 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Activator Alternative splicing Nucleus Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9767224] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Med20 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | MED20_MOUSE Q3UJQ7 Q3V418 Q6PAR6 |
| sequenceLength | 212 |
| species | [Species:48892] Mus musculus |
| (isoformParent) | [ReferenceIsoform:237027] UniProt:Q9R0X0-2 Med20 [Mus musculus] [ReferenceIsoform:237028] UniProt:Q9R0X0-3 Med20 [Mus musculus] [ReferenceIsoform:415227] UniProt:Q9R0X0-1 Med20 [Mus musculus] |
| (referenceEntity) | [EntityWithAccessionedSequence:556763] Med20 [nucleoplasm] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q9R0X0 Med20 (103792)
