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Details on Person UniProt:P18475 tor
Class:Id
ReferenceGeneProduct:103639
_chainChangeLog
signal peptide:1-20 added on Sat February 7 2015;chain:21-923 added on Sat February 7 2015
_displayName
UniProt:P18475 tor
_timestamp
2025-02-21 19:44:15
chain
signal peptide:1-20 chain:21-923
checksum
746F46E1A4277ACF
comment
FUNCTION Probable receptor tyrosine kinase which is required for determination of anterior and posterior terminal structures in the embryo (PubMed:2927509, PubMed:8423783). During postembryonic development, involved in the initiation of metamorphosis probably by inducing the production of ecdysone in response to prothoracicotropic hormone Ptth (PubMed:19965758). Binding to Ptth stimulates activation of canonical MAPK signaling leading to ERK phosphorylation (By similarity).CATALYTIC ACTIVITY L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)COFACTOR Expressed both maternally and zygotically. Expressed throughout the embryo but is activated specifically at the poles (PubMed:19965758, PubMed:2927509, PubMed:8423783). Expressed in the prothoracic gland in wandering L3 larvae (PubMed:19965758).PTM May be auto-phosphorylated on tyrosine residues.DISRUPTION PHENOTYPE RNAi-mediated knockdown in the prothoracic gland (PG) delays the onset of pupariation by prolonging the L3 larval stage. In addition, pupal size and, to a lesser extent, PG cell size are increased.SIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family.
