THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE.
WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE
Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to
assemble and peer-review its pathway modules. The integration of ORCID within Reactome
enables us to meet a key challenge with authoring, curating and reviewing biological
information by incentivizing and crediting the external experts that contribute their
expertise and time to the Reactome curation process. More information is available at
ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please
forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P50284 Ltbr
Class:Id
ReferenceGeneProduct:103599
_chainChangeLog
signal peptide:1-30 added on Fri February 6 2015;chain:31-415 added on Fri February 6 2015
_displayName
UniProt:P50284 Ltbr
_timestamp
2024-08-09 18:48:08
chain
signal peptide:1-30 chain:31-415
checksum
29B326A566AEF661
comment
FUNCTION Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Activates NF-kappa-B signaling upon stimulation with lymphotoxin. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.FUNCTION (Microbial infection) Plays a role in host defense against Zika virus infection.SUBUNIT Self-associates; dimerization and trimerization are promoted by lymphotoxin (LTA(3)) (PubMed:29507355). Associates with TRAF3 (By similarity). Associates with TRAF4 (By similarity). Associates with TRAF5 (PubMed:8663299).INTERACTION Aedes aegypti lymphotoxin beta receptor inhibitor reduces dimerization and trimerization of LTBR induced by lymphotoxin (LTA(3)).
