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Details on Person UniProt:P06804 Tnf
| Class:Id | ReferenceGeneProduct:103588 |
|---|---|
| _chainChangeLog | chain:1-235 added on Sat February 7 2015;chain:1-39 added on Sat February 7 2015;chain:1-35 added on Sat February 7 2015;chain:50- added on Sat February 7 2015;chain:52- added on Sat February 7 2015;chain:80-235 added on Sat February 7 2015 |
| _displayName | UniProt:P06804 Tnf |
| _timestamp | 2023-11-03 16:48:34 |
| chain | chain:1-235 chain:1-39 chain:1-35 chain:50- chain:52- chain:80-235 |
| checksum | 16DD2A9676D68C5D |
| comment | FUNCTION Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (PubMed:25586176). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity). Promotes osteoclastogenesis and therefore mediates bone resorption (PubMed:32741026).FUNCTION The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.SUBUNIT Interacts with SPPL2B (By similarity). Homotrimer.SUBCELLULAR LOCATION The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space (By similarity). The soluble form derives from the membrane form by proteolytic processing.PTM The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1 (By similarity).PTM O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.PTM The soluble form is demyristoylated by SIRT6, promoting its secretion.SIMILARITY Belongs to the tumor necrosis factor family. |
| description | recommendedName: Tumor necrosis factor alternativeName: Cachectin alternativeName: TNF-alpha alternativeName: Tumor necrosis factor ligand superfamily member 2 shortName: TNF-a component recommendedName: Tumor necrosis factor, membrane form alternativeName: N-terminal fragment shortName: NTF /component component recommendedName: Intracellular domain 1 shortName: ICD1 /component component recommendedName: Intracellular domain 2 shortName: ICD2 /component component recommendedName: C-domain 1 /component component recommendedName: C-domain 2 /component component recommendedName: Tumor necrosis factor, soluble form /component |
| geneName | Tnf Tnfa Tnfsf2 |
| identifier | P06804 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Cytokine Direct protein sequencing Disulfide bond Glycoprotein Lipoprotein Membrane Myristate Phosphoprotein Reference proteome Secreted Signal-anchor Transmembrane Transmembrane helix |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9698430] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Tnf |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | TNFA_MOUSE O35853 Q62326 Q91VF3 |
| sequenceLength | 235 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:976201] Tnf [extracellular region] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:P06804 Tnf (103588)
