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Details on Person UniProt:Q61371 Ift88
| Class:Id | ReferenceGeneProduct:103302 |
|---|---|
| _chainChangeLog | chain:1-824 added on Fri February 6 2015 |
| _displayName | UniProt:Q61371 Ift88 |
| _timestamp | 2026-02-20 22:00:03 |
| chain | chain:1-824 |
| checksum | BC239BA4B8FE3B5D |
| comment | FUNCTION Positively regulates primary cilium biogenesis (PubMed:11062270, PubMed:21289087, PubMed:31761534). Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.SUBUNIT Component of the IFT complex B, at least composed of IFT20, IFT22, IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88 (PubMed:19253336, PubMed:23810713). Interacts with IFT20, IFT22, IFT25, IFT27, IFT52, TRAF3IP1, IFT74, IFT80 and IFT81 (PubMed:19253336). Interacts with IFT172 (PubMed:11062270). Interacts with IFT57 (PubMed:11062270, PubMed:19253336, PubMed:23810713). Interacts with IFT46 (PubMed:17312020, PubMed:19253336). Interacts with IFT70B (PubMed:23810713). Interacts with C2CD3 (PubMed:24469809). Interacts with ENTR1 (via N-terminus) (By similarity). Interacts with LRRC56 (By similarity). Interacts with DZIP1 (PubMed:23955340). Interacts with CCDC38 (PubMed:35587122). Interacts with CCDC146 (PubMed:38038747). Interacts with CFAP53 (PubMed:34124066).SUBCELLULAR LOCATION Colocalizes with ENTR1 and gamma-tubulin at the basal body of primary cilia (By similarity). Colocalizes with ENTR1 and pericentrin at the centrosome (By similarity). In sperm cells, localizes to the manchette, head-tail coupling apparatus and flagellum (PubMed:34124066). Localizes to the manchette in elongating spermatids in a CFAP70-dependent manner (PubMed:37352829).TISSUE SPECIFICITY Testis.DEVELOPMENTAL STAGE In the testis, first observed in round spermatid flagella and continues to be detected in elongated spermatids (at protein level).DISEASE Defects in Ift88 are the cause of recessive bilateral polycystic kidney disease (PKD) with collecting duct and tubule ectasia, and a liver lesion involving biliary dysplasia and/or portal fibrosis.DISRUPTION PHENOTYPE Cilia absent or reduced, virtually no cilia of the normal 5 uM mean length (PubMed:21289087). Conditional knockdown in preadipocytes results in loss of cilia. Mutant mice show a significant reduction of gonadal white adipose tissue and total fat mass associated with reduced serum LEP levels (PubMed:31761534).SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: Intraflagellar transport protein 88 homolog alternativeName: Recessive polycystic kidney disease protein Tg737 alternativeName: Tetratricopeptide repeat protein 10 shortName: TPR repeat protein 10 alternativeName: TgN(Imorpk)737Rpw |
| geneName | Ift88 Tg737 Tg737Rpw TgN737Rpw Ttc10 |
| identifier | Q61371 |
| isSequenceChanged | FALSE |
| keyword | Cell projection Cilium Cilium biogenesis/degradation Cytoplasm Cytoskeleton Flagellum Reference proteome Repeat TPR repeat |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9688885] Weiser, JD [InstanceEdit:9698430] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9819394] Weiser, Joel [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | Ift88 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | IFT88_MOUSE E9QKU0 Q3UXY9 Q921J5 |
| sequenceLength | 824 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:5617787] Ift88 [cilium] [Mus musculus] [EntityWithAccessionedSequence:9640108] Misfolded Ift88 [cilium] [Mus musculus] [EntityWithAccessionedSequence:9640119] Misfolded Ift88 [cytosol] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q61371 Ift88 (103302)
