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Details on Person UniProt:Q99MV1 Tdrd1
| Class:Id | ReferenceGeneProduct:103198 |
|---|---|
| _chainChangeLog | chain:1-1172 added on Sat February 7 2015 |
| _displayName | UniProt:Q99MV1 Tdrd1 |
| _timestamp | 2023-11-03 17:08:59 |
| chain | chain:1-1172 |
| checksum | EF42786CAD71933D |
| comment | FUNCTION Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins.SUBUNIT Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Interacts with MAEL. Interacts with PIWIL1, PIWIL2 and PIWIL4 (when methylated on arginine residues). Interacts with TDRD12.INTERACTION Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis (PubMed:20439430). DDX4 is required for meiotic nuage localization. Also present in chromatoid body.TISSUE SPECIFICITY Testis and ovary specific. Present in germ-line cells and is most abundant in fetal prospermatogonia and postnatal primary spermatocytes (at protein level).DOMAIN Tudor domains 2 and 3 have higher affinity for arginine-methylated peptides, tudor domain 1 is a poor binder due to an impaired aromatic cage.DISRUPTION PHENOTYPE Male sterility because of postnatal spermatogenic defects due to demethylation and subsequent derepression of transposable elements. Piwi-associated small RNA profiles are altered, piRNPs accepting the entry of abundant cellular transcripts into the piRNA pathway and accumulating piRNAs with a profile that is drastically different from wild-type. Piwi proteins are delocalized from the nucleus to the cytoplasm.SIMILARITY Belongs to the TDRD1 family. |
| description | recommendedName: Tudor domain-containing protein 1 |
| geneName | Tdrd1 |
| identifier | Q99MV1 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cytoplasm Developmental protein Differentiation Meiosis Metal-binding Reference proteome Repeat RNA-mediated gene silencing Spermatogenesis Zinc Zinc-finger |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:5083144] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Tdrd1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | TDRD1_MOUSE A2VDG6 Q6F3G0 Q8CDN7 Q8K1G3 |
| sequenceLength | 1172 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:5605390] Tdrd1 [cytosol] [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q99MV1 Tdrd1 (103198)
