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Details on Person UniProt:P52633 Stat6

Class:Id	ReferenceGeneProduct:102396
_chainChangeLog	initiator methionine:1 added on Fri February 6 2015;chain:2-837 added on Fri February 6 2015;initiator methionine:1 for 102396 removed on Fri Nov 03 2023;initiator methionine: for 102396 added on Fri Nov 03 2023;initiator methionine: for 102396 removed on Fri Aug 15 2025;initiator methionine:1 for 102396 added on Fri Aug 15 2025
_displayName	UniProt:P52633 Stat6
_timestamp	2025-08-15 21:11:28
chain	initiator methionine:1 chain:2-837
checksum	082E0A15C7457307
comment	FUNCTION Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.SUBUNIT Forms a homodimer or a heterodimer with a related family member. Interacts with NCOA1 via its C-terminal LXXLL motif (By similarity).INTERACTION Translocated into the nucleus in response to phosphorylation.PTM Tyrosine phosphorylated on Tyr-641 following stimulation by IL4/interleukin-4. Tyrosine phosphorylated following stimulation by IL3/interleukin-3. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling.PTM Mono-ADP-ribosylated by PARP14.SIMILARITY Belongs to the transcription factor STAT family.
description	recommendedName: Signal transducer and transcription activator 6
geneName	Stat6
identifier	P52633
isSequenceChanged	FALSE
keyword	Acetylation Activator ADP-ribosylation Cytoplasm DNA-binding Nucleus Phosphoprotein Reference proteome SH2 domain Transcription Transcription regulation
modified	[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5083144] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
name	Stat6
referenceDatabase	[ReferenceDatabase:2] UniProt
secondaryIdentifier	STAT6_MOUSE Q8R2F1
sequenceLength	837
species	[Species:48892] Mus musculus
(referenceEntity)	[EntityWithAccessionedSequence:8983167] Stat6 [cytosol] [Mus musculus] [EntityWithAccessionedSequence:8983176] p-Stat6 [cytosol] [Mus musculus] [EntityWithAccessionedSequence:9007114] Stat6 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:9007133] p-Y-Stat6 [cytosol] [Mus musculus] [EntityWithAccessionedSequence:9007147] p-Y-Stat6 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:9007308] p-Stat6 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:9967194] p-Y641-Stat6 [nucleoplasm] [Mus musculus]
(referenceSequence)	[ModifiedResidue:8983196] phosphorylated residue at unknown position [ModifiedResidue:9007152] O4'-phospho-L-tyrosine at unknown position [ModifiedResidue:9967235] O4'-phospho-L-tyrosine at 641
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No pathways have been reviewed or authored by UniProt:P52633 Stat6 (102396)