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Details on Person UniProt:Q8IWX5 SGPP2
| Class:Id | ReferenceGeneProduct:102130 |
|---|---|
| _chainChangeLog | chain:1-399 added on Sat February 7 2015 |
| _displayName | UniProt:Q8IWX5 SGPP2 |
| _timestamp | 2025-02-21 19:32:52 |
| chain | chain:1-399 |
| checksum | 7615BA231263D0B6 |
| comment | FUNCTION Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro (PubMed:12411432). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (By similarity). May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling (PubMed:17113265). Plays a role in the regulation of pancreatic islet beta-cell endoplasmic reticulum stress and proliferation (By similarity).CATALYTIC ACTIVITY sphinganine 1-phosphate + H2O = sphinganine + phosphateCATALYTIC ACTIVITY sphing-4-enine 1-phosphate + H2O = sphing-4-enine + phosphateCATALYTIC ACTIVITY (4R)-hydroxysphinganine 1-phosphate + H2O = (4R)-hydroxysphinganine + phosphateSUBCELLULAR LOCATION Expressed strongly in kidney and heart, followed by brain, colon, small intestine and lung. Not detected in skeletal muscle, thymus, spleen, liver, placenta, and peripheral blood leukocytes.INDUCTION Strongly induced by TNF, also induced by bacterial lipopolycaccharides (LPS) in neutrophils, endothelial cells, and other cell types. Not induced by growth-related factors.SIMILARITY Belongs to the type 2 lipid phosphate phosphatase family. |
| description | recommendedName: fullName evidence="10"Sphingosine-1-phosphate phosphatase 2 shortName: SPPase2 shortName: Spp2 shortName: hSPP2 ecNumber evidence="5 7"3.1.3.- alternativeName: Sphingosine-1-phosphatase 2 |
| geneName | SGPP2 |
| identifier | Q8IWX5 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Endoplasmic reticulum Hydrolase Lipid metabolism Membrane Proteomics identification Reference proteome Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | SGPP2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988665] ENSEMBL:ENSG00000163082 SGPP2 [Homo sapiens] |
| secondaryIdentifier | SGPP2_HUMAN A3KPB4 Q8N8Q6 |
| sequenceLength | 399 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8973070] UniProt:Q8IWX5-1 SGPP2 [Homo sapiens] [ReferenceIsoform:8973071] UniProt:Q8IWX5-2 SGPP2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:428658] SGPP2 [endoplasmic reticulum membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q8IWX5 SGPP2 (102130)
