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Details on Person UniProt:Q62261 Sptbn1
| Class:Id | ReferenceGeneProduct:102086 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-2363 added on Sat February 7 2015;initiator methionine:1 for 102086 removed on Fri Nov 03 2023;initiator methionine: for 102086 added on Fri Nov 03 2023;initiator methionine: for 102086 removed on Fri Aug 15 2025;initiator methionine:1 for 102086 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q62261 Sptbn1 |
| _timestamp | 2025-08-15 21:19:04 |
| chain | initiator methionine:1 chain:2-2363 |
| checksum | 221362054E64BB8C |
| comment | FUNCTION Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function.SUBUNIT Interacts with ANK2 (PubMed:15262991). Interacts with CPNE4 (via VWFA domain) (PubMed:12522145). Like erythrocyte spectrin, the spectrin-like proteins are capable to form dimers which can further associate to tetramers (By similarity). Interacts with CAMSAP1 (By similarity). Can form heterodimers with SPTAN1.SUBCELLULAR LOCATION Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes.SUBCELLULAR LOCATION Isoform 2 is present in brain, heart, kidney and liver (at protein level).DEVELOPMENTAL STAGE Isoform 2 is expressed in brain, heart and liver throughout embryonic development. Isoform 1 is mainly expressed in neonatal developing ventricular cardiomyocytes.SIMILARITY Belongs to the spectrin family. |
| description | recommendedName: Spectrin beta chain, non-erythrocytic 1 alternativeName: Beta-II spectrin alternativeName: Embryonic liver fodrin alternativeName: Fodrin beta chain |
| geneName | Sptbn1 Elf Spnb-2 Spnb2 Sptb2 |
| identifier | Q62261 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Actin capping Actin-binding Alternative splicing Calmodulin-binding Cell membrane Cytoplasm Cytoskeleton Glycoprotein Membrane Phosphoprotein Reference proteome Repeat |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Sptbn1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | SPTB2_MOUSE A2AFU1 Q3TEM7 Q5SQL8 Q5SQL9 Q9QWJ7 |
| sequenceLength | 2363 |
| species | [Species:48892] Mus musculus |
| (isoformParent) | [ReferenceIsoform:249305] UniProt:Q62261-2 Sptbn1 [Mus musculus] [ReferenceIsoform:407706] UniProt:Q62261-1 Sptbn1 [Mus musculus] |
| (referenceEntity) | [EntityWithAccessionedSequence:9662390] Sptbn1 [cytosol] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q62261 Sptbn1 (102086)
