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Details on Person UniProt:O95347 SMC2
| Class:Id | ReferenceGeneProduct:101781 |
|---|---|
| _chainChangeLog | chain:1-1197 added on Fri February 6 2015 |
| _displayName | UniProt:O95347 SMC2 |
| _timestamp | 2024-11-03 19:54:01 |
| chain | chain:1-1197 |
| checksum | 15EBB56B31FC1364 |
| comment | FUNCTION Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.SUBUNIT Forms a heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG. Interacts with BRD4 (isoform B), leading to insulate chromatin from DNA damage response pathway.INTERACTION In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.ALTERNATIVE PRODUCTS The SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC4, forming a V-shaped heterodimer.SIMILARITY Belongs to the SMC family. SMC2 subfamily. |
| description | recommendedName: Structural maintenance of chromosomes protein 2 shortName: SMC protein 2 shortName: SMC-2 alternativeName: Chromosome-associated protein E shortName: hCAP-E alternativeName: XCAP-E homolog |
| geneName | SMC2 CAPE SMC2L1 PRO0324 |
| identifier | O95347 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing ATP-binding Cell cycle Cell division Chromosome Coiled coil Cytoplasm DNA condensation Mitosis Nucleotide-binding Nucleus Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SMC2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993899] ENSEMBL:ENSG00000136824 SMC2 [Homo sapiens] |
| secondaryIdentifier | SMC2_HUMAN Q6IEE0 Q9P1P2 |
| sequenceLength | 1197 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:154062] UniProt:O95347-2 SMC2 [Homo sapiens] [ReferenceIsoform:402132] UniProt:O95347-1 SMC2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:1629792] SMC2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:2517875] SMC2 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O95347 SMC2 (101781)
