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Details on Person Expression of IFN-induced genes

Class:Id	BlackBoxEvent:1015702
_displayName	Expression of IFN-induced genes
_doRelease	TRUE
_timestamp	2023-05-16 21:26:37
authored	[InstanceEdit:909728] Garapati, P V, 2010-07-07
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:1015701] Garapati, P V, 2010-11-15
edited	[InstanceEdit:909728] Garapati, P V, 2010-07-07
input	[DefinedSet:9034125] Type I IFN-regulated genes with ISRE promoter elements [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9835581] Matthews, Lisa, 2023-05-16
isChimeric	FALSE
literatureReference	[LiteratureReference:1015626] Novel growth and death related interferon-stimulated genes (ISGs) in melanoma: greater potency of IFN-beta compared with IFN-alpha2 [LiteratureReference:1014316] Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays [LiteratureReference:1015644] Functional classification of interferon-stimulated genes identified using microarrays [LiteratureReference:1015647] Gene structure and function of the 2'-5'-oligoadenylate synthetase family [LiteratureReference:1015650] Identification of X-linked inhibitor of apoptosis-associated factor-1 as an interferon-stimulated gene that augments TRAIL Apo2L-induced apoptosis [LiteratureReference:1015648] Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells [LiteratureReference:1015668] A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis [LiteratureReference:1015669] Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways [LiteratureReference:1015664] Human MxA protein inhibits the replication of Crimean-Congo hemorrhagic fever virus [LiteratureReference:1015638] Interferon action--sequence specificity of the ppp(A2'p)nA-dependent ribonuclease [LiteratureReference:1015642] Differential expression and distinct structure of 69- and 100-kDa forms of 2-5A synthetase in human cells treated with interferon [LiteratureReference:1031687] Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells [LiteratureReference:1031655] Regulation of the Egr-1 gene by tumor necrosis factor and interferons in primary human fibroblasts [LiteratureReference:9690049] Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance [LiteratureReference:9690050] Distinct and overlapping genomic profiles and antiviral effects of Interferon-λ and -α on HCV-infected and noninfected hepatoma cells [LiteratureReference:9833475] Interferon-associated, dsRNA-dependent enzyme activities in a mutant 3T6 cell engaged in the semiconstitutive synthesis of interferon
modified	[InstanceEdit:1015703] Garapati, P V, 2010-11-15 [InstanceEdit:1031715] Garapati, P V, 2010-11-18 [InstanceEdit:5624200] Garapati, P V, 2014-09-22 [InstanceEdit:9034308] Orlic-Milacic, Marija, 2018-01-03 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9690051] Shamovsky, Veronica, 2020-05-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9833476] Stephan, Ralf, 2023-04-27 [InstanceEdit:9835582] Matthews, Lisa, 2023-05-16
name	Expression of IFN-induced genes
output	[EntityWithAccessionedSequence:53939] ADAR [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:937341] IFIT1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:1015674] IFIT2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:947491] IFIT3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:936552] ISG15 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:1015671] ISG20 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:947487] IFI6 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:947492] IFI35 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:199523] IFITM1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:174336] PSMB8 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:1015677] IFI27 [mitochondrial outer membrane] [Homo sapiens] [EntityWithAccessionedSequence:1015682] IFITM2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:1015688] IFITM3 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:1015684] RNASEL [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:1015673] GBP2 [cytosol] [Homo sapiens] [DefinedSet:1015693] Mx GTPases [cytosol] [Homo sapiens] [DefinedSet:1015696] OAS proteins [cytosol] [Homo sapiens] [DefinedSet:1015695] IRF 1-9 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:1015680] XAF1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:1015687] IP6K2 [nucleoplasm] [Homo sapiens] [DefinedSet:983117] monoglucosylated Class I MHC heavy chain (MHC HC) [lumenal side of endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:1031703] EGR1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5624196] BST2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:5624199] RSAD2 [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:5624198] SAMHD1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9684472] IFIT5 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:168699] EIF2AK2 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:1015699] ISGF3 binds the ISRE promoter elements in IFN-stimulated genes [Homo sapiens] [Reaction:909721] Translocation of ISGF3 complex to nucleus [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[PositiveRegulation:1031720] Positive regulation by 'ISGF3 bound to ISRE promotor elements [nucleoplasm]'
releaseDate	2010-12-14
reviewed	[InstanceEdit:933762] Abdul-Sater, AA, Schindler, C, 2010-08-17
reviewStatus	[ReviewStatus:9821385] four stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105119] R-HSA-1015702.5
structureModified	[InstanceEdit:9833476] Stephan, Ralf, 2023-04-27
summation	[Summation:1014322] Around 300 IFN-induced genes have been identified from diffe...
(hasEvent)	[Pathway:909733] Interferon alpha/beta signaling [Homo sapiens]
(precedingEvent)	[Reaction:8866601] SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate [Homo sapiens] [Reaction:8983671] OAS1 binds viral dsRNA intermediates produced by (+)ssRNA virus [Homo sapiens] [Reaction:8985138] OAS2 binds viral dsRNA [Homo sapiens] [Reaction:8985153] OASL binds DDX58 [Homo sapiens] [Reaction:8985157] OAS3 binds viral dsRNA intermediates produced by (+)ssRNA virus [Homo sapiens] [BlackBoxEvent:9833635] p-PKR dimer localizes to the nucleus [Homo sapiens] [Reaction:9833723] PKR forms a dimer [Homo sapiens] [Reaction:9909519] IFI44, IFI44L binds FKBP5 [Homo sapiens] [Reaction:9947999] FNTA:PGGT1B geranylgeranylates GBP2 [Homo sapiens] [Reaction:9954195] FNTA:PGGT1B geranylgeranylates GBP5 [Homo sapiens] List all 12 refering instances
(updatedInstance)	[_UpdateTracker:9776999] Update Tracker - [BlackBoxEvent:1015702] Expression of IFN-induced genes - v73:[addLiteratureReference, addOutput] [_UpdateTracker:9780157] Update Tracker - [BlackBoxEvent:1015702] Expression of IFN-induced genes - v64:[addInput] [_UpdateTracker:9785708] Update Tracker - [BlackBoxEvent:1015702] Expression of IFN-induced genes - v51:[addOutput] [_UpdateTracker:9835713] Update Tracker - [BlackBoxEvent:1015702] Expression of IFN-induced genes - v85:[addLiteratureReference, addOutput]
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