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Details on Person UniProt:O95470 SGPL1
| Class:Id | ReferenceGeneProduct:101503 |
|---|---|
| _chainChangeLog | chain:1-568 added on Sat February 7 2015 |
| _displayName | UniProt:O95470 SGPL1 |
| _timestamp | 2024-11-03 19:58:34 |
| chain | chain:1-568 |
| checksum | 3B16FDEFC4B2FDB6 |
| comment | FUNCTION Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (PubMed:11018465, PubMed:14570870, PubMed:24809814, PubMed:28165339). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity).CATALYTIC ACTIVITY sphinganine 1-phosphate = hexadecanal + phosphoethanolamineCATALYTIC ACTIVITY sphing-4-enine 1-phosphate = (2E)-hexadecenal + phosphoethanolamineCOFACTOR Lipid metabolism; sphingolipid metabolism.SUBUNIT Homodimer.INTERACTION Ubiquitously expressed (PubMed:11018465, PubMed:28165343). Expressed in fetal and adult adrenal gland (at protein level) (PubMed:28165343).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: fullName evidence="15"Sphingosine-1-phosphate lyase 1 shortName evidence="15"S1PL shortName evidence="15"SP-lyase 1 shortName evidence="15"SPL 1 shortName: hSPL ecNumber evidence="4 6 7 9"4.1.2.27 alternativeName: Sphingosine-1-phosphate aldolase |
| geneName | SGPL1 KIAA1252 |
| identifier | O95470 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Apoptosis Disease variant Endoplasmic reticulum Lipid metabolism Lyase Membrane Nitration Phosphoprotein Proteomics identification Pyridoxal phosphate Reference proteome Signal-anchor Sphingolipid metabolism Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SGPL1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002054] ENSEMBL:ENSG00000166224 SGPL1 [Homo sapiens] |
| secondaryIdentifier | SGPL1_HUMAN B2RBD4 Q7Z732 Q9ULG8 Q9UN89 |
| sequenceLength | 568 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:428661] PXLP-SGPL1 [endoplasmic reticulum membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:554224] N6-pyridoxal phosphate-L-lysine at 353 |
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No pathways have been reviewed or authored by UniProt:O95470 SGPL1 (101503)
