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Details on Person UniProt:Q96I25 RBM17
| Class:Id | ReferenceGeneProduct:101441 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-401 added on Sat February 7 2015;initiator methionine:1 for 101441 removed on Fri Nov 03 2023;initiator methionine: for 101441 added on Fri Nov 03 2023;initiator methionine: for 101441 removed on Fri Aug 15 2025;initiator methionine:1 for 101441 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q96I25 RBM17 |
| _timestamp | 2025-08-15 21:49:20 |
| chain | initiator methionine:1 chain:2-401 |
| checksum | 99FA8C5E5E998554 |
| comment | FUNCTION Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia.SUBUNIT Binds SXL. Associates with the spliceosome. Interacts with SF3B1, SF1 and U2AF2. |
| description | recommendedName: Splicing factor 45 alternativeName: 45 kDa-splicing factor alternativeName: RNA-binding motif protein 17 |
| geneName | RBM17 SPF45 |
| identifier | Q96I25 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Direct protein sequencing Isopeptide bond mRNA processing mRNA splicing Nucleus Phosphoprotein Proteomics identification Reference proteome RNA-binding Spliceosome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | RBM17 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003252] ENSEMBL:ENSG00000134453 RBM17 [Homo sapiens] |
| secondaryIdentifier | SPF45_HUMAN Q96GY6 |
| sequenceLength | 401 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:8865891] RBM17 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q96I25 RBM17 (101441)
